Cargando…
Evaluation of transcranial Doppler abnormalities in children with sickle cell disease in El-Obeid Specialized Children's Hospital
OBJECTIVES: This study aims to evaluate transcranial Doppler abnormalities in children with sickle cell disease (SCD) in a specialized children's hospital in El-Obeid. MATERIALS AND METHODS: This is a cross-sectional study done on 119 patients (2–18 years of age were included) who attended the...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482797/ https://www.ncbi.nlm.nih.gov/pubmed/31041270 http://dx.doi.org/10.4103/jfmpc.jfmpc_112_19 |
_version_ | 1783413956891639808 |
---|---|
author | Ismail, Walaa Ismail Musa Elnour, Mustafa Mustafa, Alam Eldin Musa |
author_facet | Ismail, Walaa Ismail Musa Elnour, Mustafa Mustafa, Alam Eldin Musa |
author_sort | Ismail, Walaa Ismail Musa |
collection | PubMed |
description | OBJECTIVES: This study aims to evaluate transcranial Doppler abnormalities in children with sickle cell disease (SCD) in a specialized children's hospital in El-Obeid. MATERIALS AND METHODS: This is a cross-sectional study done on 119 patients (2–18 years of age were included) who attended the sickle cell clinic in a specialized children's hospital in El-Obeid from December 2016 to February 2017; when patients do not have recent stroke symptoms, blood flow velocities were measured in both proximal internal carotid and middle cerebral arteries (MCAs) using non-imaging Doppler method, and time average mean velocities were recorded along with hemoglobin concentration and of the patients. RESULTS: None of the study population had MCA velocity higher than 200 cm/s; also no high conditional velocity (170–199 cm/s) was recorded, so no patient was at high risk to develop stroke. About 20.1% of patients showed low velocities in one or both MCAs; 4.2% had abnormal MCAs’ interhemispheric ratio; 4.2% of study population showed absent flow in one of their MCAs, reflecting previous occlusion. About 4.2% had poor temporal window. It was difficult to measure the velocity in one of the four vessels in 5.9% of the patient due to uncooperativeness. There was statistically significant relationship between hemoglobin concentration and blood velocity in the left MCA. CONCLUSION: Despite the international recommendations, using transcranial Doppler ultrasonography (TCD) as a stroke screening tool in children with SCD in Sudan is still not a well-known practice. Successful strategies to improve TCD screening rates must be encouraged in all healthcare institutions. |
format | Online Article Text |
id | pubmed-6482797 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-64827972019-04-30 Evaluation of transcranial Doppler abnormalities in children with sickle cell disease in El-Obeid Specialized Children's Hospital Ismail, Walaa Ismail Musa Elnour, Mustafa Mustafa, Alam Eldin Musa J Family Med Prim Care Original Article OBJECTIVES: This study aims to evaluate transcranial Doppler abnormalities in children with sickle cell disease (SCD) in a specialized children's hospital in El-Obeid. MATERIALS AND METHODS: This is a cross-sectional study done on 119 patients (2–18 years of age were included) who attended the sickle cell clinic in a specialized children's hospital in El-Obeid from December 2016 to February 2017; when patients do not have recent stroke symptoms, blood flow velocities were measured in both proximal internal carotid and middle cerebral arteries (MCAs) using non-imaging Doppler method, and time average mean velocities were recorded along with hemoglobin concentration and of the patients. RESULTS: None of the study population had MCA velocity higher than 200 cm/s; also no high conditional velocity (170–199 cm/s) was recorded, so no patient was at high risk to develop stroke. About 20.1% of patients showed low velocities in one or both MCAs; 4.2% had abnormal MCAs’ interhemispheric ratio; 4.2% of study population showed absent flow in one of their MCAs, reflecting previous occlusion. About 4.2% had poor temporal window. It was difficult to measure the velocity in one of the four vessels in 5.9% of the patient due to uncooperativeness. There was statistically significant relationship between hemoglobin concentration and blood velocity in the left MCA. CONCLUSION: Despite the international recommendations, using transcranial Doppler ultrasonography (TCD) as a stroke screening tool in children with SCD in Sudan is still not a well-known practice. Successful strategies to improve TCD screening rates must be encouraged in all healthcare institutions. Wolters Kluwer - Medknow 2019-03 /pmc/articles/PMC6482797/ /pubmed/31041270 http://dx.doi.org/10.4103/jfmpc.jfmpc_112_19 Text en Copyright: © 2019 Journal of Family Medicine and Primary Care http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Ismail, Walaa Ismail Musa Elnour, Mustafa Mustafa, Alam Eldin Musa Evaluation of transcranial Doppler abnormalities in children with sickle cell disease in El-Obeid Specialized Children's Hospital |
title | Evaluation of transcranial Doppler abnormalities in children with sickle cell disease in El-Obeid Specialized Children's Hospital |
title_full | Evaluation of transcranial Doppler abnormalities in children with sickle cell disease in El-Obeid Specialized Children's Hospital |
title_fullStr | Evaluation of transcranial Doppler abnormalities in children with sickle cell disease in El-Obeid Specialized Children's Hospital |
title_full_unstemmed | Evaluation of transcranial Doppler abnormalities in children with sickle cell disease in El-Obeid Specialized Children's Hospital |
title_short | Evaluation of transcranial Doppler abnormalities in children with sickle cell disease in El-Obeid Specialized Children's Hospital |
title_sort | evaluation of transcranial doppler abnormalities in children with sickle cell disease in el-obeid specialized children's hospital |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482797/ https://www.ncbi.nlm.nih.gov/pubmed/31041270 http://dx.doi.org/10.4103/jfmpc.jfmpc_112_19 |
work_keys_str_mv | AT ismailwalaaismailmusa evaluationoftranscranialdopplerabnormalitiesinchildrenwithsicklecelldiseaseinelobeidspecializedchildrenshospital AT elnourmustafa evaluationoftranscranialdopplerabnormalitiesinchildrenwithsicklecelldiseaseinelobeidspecializedchildrenshospital AT mustafaalameldinmusa evaluationoftranscranialdopplerabnormalitiesinchildrenwithsicklecelldiseaseinelobeidspecializedchildrenshospital |