Next-generation sequencing of BRCA1 and BRCA2 genes for rapid detection of germline mutations in hereditary breast/ovarian cancer

BACKGROUND: Conventional methods used to identify BRCA1 and BRCA2 germline mutations in hereditary cancers, such as Sanger sequencing/multiplex ligation-dependent probe amplification (MLPA), are time-consuming and expensive, due to the large size of the genes. The recent introduction of next-generat...

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Detalles Bibliográficos
Autores principales: Nicolussi, Arianna, Belardinilli, Francesca, Mahdavian, Yasaman, Colicchia, Valeria, D’Inzeo, Sonia, Petroni, Marialaura, Zani, Massimo, Ferraro, Sergio, Valentini, Virginia, Ottini, Laura, Giannini, Giuseppe, Capalbo, Carlo, Coppa, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2019
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482939/
https://www.ncbi.nlm.nih.gov/pubmed/31065452
http://dx.doi.org/10.7717/peerj.6661

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