Cargando…
Low genetic heterogeneity of copy number variations (CNVs) in the genes encoding the human deoxyribonucleases 1-like 3 and II potentially relevant to autoimmunity
Deoxyribonucleases (DNases) might play a role in prevention of autoimmune conditions such as systemic lupus erythematosus through clearance of cell debris resulting from apoptosis and/or necrosis. Previous studies have suggested that variations in the in vivo activities of DNases I-like 3(1L3) and I...
Autores principales: | Ueki, Misuzu, Fujihara, Junko, Kimura-Kataoka, Kaori, Yamada, Kazuo, Takinami, Yoshikazu, Takeshita, Haruo, Iida, Reiko, Yasuda, Toshihiro |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483174/ https://www.ncbi.nlm.nih.gov/pubmed/31022206 http://dx.doi.org/10.1371/journal.pone.0215479 |
Ejemplares similares
-
Evaluation of the functional effects of genetic variants‒missense and nonsense SNPs, indels and copy number variations‒in the gene encoding human deoxyribonuclease I potentially implicated in autoimmunity
por: Ueki, Misuzu, et al.
Publicado: (2019) -
Survey of single-nucleotide polymorphisms in the gene encoding human deoxyribonuclease I-like 2 producing loss of function potentially implicated in the pathogenesis of parakeratosis
por: Ueki, Misuzu, et al.
Publicado: (2017) -
Three Nonsynonymous Single Nucleotide Polymorphisms in the RhitH Gene Cause Reduction of the Repression Activity That Leads to Upregulation of M-LPH, a Participant in Mitochondrial Function
por: Iida, Reiko, et al.
Publicado: (2013) -
Knockout of Mpv17-Like Protein (M-LPH) Gene in Human Hepatoma Cells Results in Impairment of mtDNA Integrity through Reduction of TFAM, OGG1, and LIG3 at the Protein Levels
por: Iida, Reiko, et al.
Publicado: (2018) -
Copy number variations (CNVs) identified in Korean individuals
por: Kang, Tae-Wook, et al.
Publicado: (2008)