A negative role for the interleukin-2-inducible T-cell kinase (ITK) in human Foxp3(+) T(REG) differentiation

The Tec kinases ITK (interleukin-2-inducible T-cell kinase) and RLK (resting lymphocyte kinase) are critical components of the proximal TCR/CD3 signal transduction machinery, and data in mice suggest that ITK negatively modulates regulatory T cell (T(REG)) differentiation. However, whether Tec kinas...

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Detalles Bibliográficos
Autores principales: Mamontov, Polina, Eberwine, Ryan A., Perrigoue, Jackie, Das, Anuk, Friedman, Joshua R., Mora, J. Rodrigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483201/
https://www.ncbi.nlm.nih.gov/pubmed/31022269
http://dx.doi.org/10.1371/journal.pone.0215963

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