HMGB proteins are required for sexual development in Aspergillus nidulans

Aspergillus nidulans has three high mobility group box (HMGB) proteins, HmbA, HmbB and HmbC that are chromatin-associated architectural proteins involved in DNA-related functions. By creating and studying deletion strains in both veA(+) and veA1 background, we have characterized the role of HmbA, Hm...

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Detalles Bibliográficos
Autores principales: Bokor, Eszter, Ámon, Judit, Keisham, Kabichandra, Karácsony, Zoltán, Vágvölgyi, Csaba, Hamari, Zsuzsanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483251/
https://www.ncbi.nlm.nih.gov/pubmed/31022275
http://dx.doi.org/10.1371/journal.pone.0216094
Descripción
Sumario:Aspergillus nidulans has three high mobility group box (HMGB) proteins, HmbA, HmbB and HmbC that are chromatin-associated architectural proteins involved in DNA-related functions. By creating and studying deletion strains in both veA(+) and veA1 background, we have characterized the role of HmbA, HmbB and HmbC in sexual development. Expression of the mating-type MAT1-1 and MAT1-2 coding genes were found to be extremely down-regulated in all three mutants on day 4 of sexual development, which results in deficient ascospore production and/or ascospore viability in the mutants. In addition, we found that HmbA and HmbB play also a role in sensing of and response to environmental signals, while HmbC functionally interacts with VeA, a key regulator of the coordination of asexual and sexual development, as well as of secondary metabolism.

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