Acute Tubular Necrosis Associated With High Serum Vancomycin and Tobramycin Levels After Revision of Total Knee Arthroplasty With Antibiotic-Containing Calcium Sulfate Beads

We present the case of a 59-year-old male who developed acute tubular necrosis with a serum tobramycin level of 15.9 mg/L after instillation of tobramycin and vancomycin calcium sulfate beads for infected total knee arthroplasty. We emphasize standardizing surgical protocols to mitigate nephrotoxici...

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Detalles Bibliográficos
Autores principales: Ma, Adrienne H, Hoffman, Courtney, Mcneil, John I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483752/
https://www.ncbi.nlm.nih.gov/pubmed/31041345
http://dx.doi.org/10.1093/ofid/ofz141
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author Ma, Adrienne H
Hoffman, Courtney
Mcneil, John I
author_facet Ma, Adrienne H
Hoffman, Courtney
Mcneil, John I
author_sort Ma, Adrienne H
collection PubMed
description We present the case of a 59-year-old male who developed acute tubular necrosis with a serum tobramycin level of 15.9 mg/L after instillation of tobramycin and vancomycin calcium sulfate beads for infected total knee arthroplasty. We emphasize standardizing surgical protocols to mitigate nephrotoxicity based on current efficacy and safety data.
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spelling pubmed-64837522019-04-30 Acute Tubular Necrosis Associated With High Serum Vancomycin and Tobramycin Levels After Revision of Total Knee Arthroplasty With Antibiotic-Containing Calcium Sulfate Beads Ma, Adrienne H Hoffman, Courtney Mcneil, John I Open Forum Infect Dis Brief Report We present the case of a 59-year-old male who developed acute tubular necrosis with a serum tobramycin level of 15.9 mg/L after instillation of tobramycin and vancomycin calcium sulfate beads for infected total knee arthroplasty. We emphasize standardizing surgical protocols to mitigate nephrotoxicity based on current efficacy and safety data. Oxford University Press 2019-04-25 /pmc/articles/PMC6483752/ /pubmed/31041345 http://dx.doi.org/10.1093/ofid/ofz141 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Ma, Adrienne H
Hoffman, Courtney
Mcneil, John I
Acute Tubular Necrosis Associated With High Serum Vancomycin and Tobramycin Levels After Revision of Total Knee Arthroplasty With Antibiotic-Containing Calcium Sulfate Beads
title Acute Tubular Necrosis Associated With High Serum Vancomycin and Tobramycin Levels After Revision of Total Knee Arthroplasty With Antibiotic-Containing Calcium Sulfate Beads
title_full Acute Tubular Necrosis Associated With High Serum Vancomycin and Tobramycin Levels After Revision of Total Knee Arthroplasty With Antibiotic-Containing Calcium Sulfate Beads
title_fullStr Acute Tubular Necrosis Associated With High Serum Vancomycin and Tobramycin Levels After Revision of Total Knee Arthroplasty With Antibiotic-Containing Calcium Sulfate Beads
title_full_unstemmed Acute Tubular Necrosis Associated With High Serum Vancomycin and Tobramycin Levels After Revision of Total Knee Arthroplasty With Antibiotic-Containing Calcium Sulfate Beads
title_short Acute Tubular Necrosis Associated With High Serum Vancomycin and Tobramycin Levels After Revision of Total Knee Arthroplasty With Antibiotic-Containing Calcium Sulfate Beads
title_sort acute tubular necrosis associated with high serum vancomycin and tobramycin levels after revision of total knee arthroplasty with antibiotic-containing calcium sulfate beads
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483752/
https://www.ncbi.nlm.nih.gov/pubmed/31041345
http://dx.doi.org/10.1093/ofid/ofz141
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AT hoffmancourtney acutetubularnecrosisassociatedwithhighserumvancomycinandtobramycinlevelsafterrevisionoftotalkneearthroplastywithantibioticcontainingcalciumsulfatebeads
AT mcneiljohni acutetubularnecrosisassociatedwithhighserumvancomycinandtobramycinlevelsafterrevisionoftotalkneearthroplastywithantibioticcontainingcalciumsulfatebeads

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