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Precise therapeutic gene correction by a simple nuclease-induced double-strand break

Current programmable nuclease-based (e.g. CRISPR-Cas9) methods for precise correction of a disease-causing genetic mutation harness the Homology Directed Repair (HDR) pathway. However, this repair process requires co-delivery of an exogenous DNA donor to recode the sequence and can be inefficient in...

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Detalles Bibliográficos
Autores principales:	Iyer, Sukanya, Suresh, Sneha, Guo, Dongsheng, Daman, Katelyn, Chen, Jennifer C. J., Liu, Pengpeng, Zieger, Marina, Luk, Kevin, Roscoe, Benjamin P., Mueller, Christian, King, Oliver D., Emerson, Charles P., Wolfe, Scot A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483862/ https://www.ncbi.nlm.nih.gov/pubmed/30944467 http://dx.doi.org/10.1038/s41586-019-1076-8

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