Effect of medetomidine on tear flow measured by Schirmer tear test I in normal pigs

Medetomidine, an α(2)-adrenoceptor agonist, was reported to decrease tear flow in some species. However, there are no reports about the effect of medetomidine on tear flow in pigs. The purpose of this study was to elucidate it. The study was performed in 10 clinically normal female Landrace pigs age...

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Detalles Bibliográficos
Autores principales: KANDA, Teppei, KAJIYAMA, Ayumu, MORIMITSU, Waka, NISHINO, Yukiko, OISHI, Yutaro, SHIMIZU, Yuki, MAETA, Noritaka, FURUMOTO, Kayo, ITOH, Yoshiki, FURUKAWA, Toshinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2019
Materias:
Surgery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483924/
https://www.ncbi.nlm.nih.gov/pubmed/30745521
http://dx.doi.org/10.1292/jvms.18-0660
Descripción
Sumario:Medetomidine, an α(2)-adrenoceptor agonist, was reported to decrease tear flow in some species. However, there are no reports about the effect of medetomidine on tear flow in pigs. The purpose of this study was to elucidate it. The study was performed in 10 clinically normal female Landrace pigs aged 3 months. Tear flow was measured by the Schirmer tear test (STT) I before (baseline) and 15 and 30 min after intramuscular administration of 80 µg/kg medetomidine. Compared to the STT I value at baseline, the value decreased significantly at 30 min after administration in both the left and right eyes. In pigs treated with medetomidine, an artificial tear solution or ophthalmic gel should be applied to protect the ocular surface.

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