Effect of medetomidine on tear flow measured by Schirmer tear test I in normal pigs

Medetomidine, an α(2)-adrenoceptor agonist, was reported to decrease tear flow in some species. However, there are no reports about the effect of medetomidine on tear flow in pigs. The purpose of this study was to elucidate it. The study was performed in 10 clinically normal female Landrace pigs age...

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Autores principales: KANDA, Teppei, KAJIYAMA, Ayumu, MORIMITSU, Waka, NISHINO, Yukiko, OISHI, Yutaro, SHIMIZU, Yuki, MAETA, Noritaka, FURUMOTO, Kayo, ITOH, Yoshiki, FURUKAWA, Toshinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2019
Materias:
Surgery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483924/
https://www.ncbi.nlm.nih.gov/pubmed/30745521
http://dx.doi.org/10.1292/jvms.18-0660
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author KANDA, Teppei
KAJIYAMA, Ayumu
MORIMITSU, Waka
NISHINO, Yukiko
OISHI, Yutaro
SHIMIZU, Yuki
MAETA, Noritaka
FURUMOTO, Kayo
ITOH, Yoshiki
FURUKAWA, Toshinori
author_facet KANDA, Teppei
KAJIYAMA, Ayumu
MORIMITSU, Waka
NISHINO, Yukiko
OISHI, Yutaro
SHIMIZU, Yuki
MAETA, Noritaka
FURUMOTO, Kayo
ITOH, Yoshiki
FURUKAWA, Toshinori
author_sort KANDA, Teppei
collection PubMed
description Medetomidine, an α(2)-adrenoceptor agonist, was reported to decrease tear flow in some species. However, there are no reports about the effect of medetomidine on tear flow in pigs. The purpose of this study was to elucidate it. The study was performed in 10 clinically normal female Landrace pigs aged 3 months. Tear flow was measured by the Schirmer tear test (STT) I before (baseline) and 15 and 30 min after intramuscular administration of 80 µg/kg medetomidine. Compared to the STT I value at baseline, the value decreased significantly at 30 min after administration in both the left and right eyes. In pigs treated with medetomidine, an artificial tear solution or ophthalmic gel should be applied to protect the ocular surface.
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spelling pubmed-64839242019-04-30 Effect of medetomidine on tear flow measured by Schirmer tear test I in normal pigs KANDA, Teppei KAJIYAMA, Ayumu MORIMITSU, Waka NISHINO, Yukiko OISHI, Yutaro SHIMIZU, Yuki MAETA, Noritaka FURUMOTO, Kayo ITOH, Yoshiki FURUKAWA, Toshinori J Vet Med Sci Surgery Medetomidine, an α(2)-adrenoceptor agonist, was reported to decrease tear flow in some species. However, there are no reports about the effect of medetomidine on tear flow in pigs. The purpose of this study was to elucidate it. The study was performed in 10 clinically normal female Landrace pigs aged 3 months. Tear flow was measured by the Schirmer tear test (STT) I before (baseline) and 15 and 30 min after intramuscular administration of 80 µg/kg medetomidine. Compared to the STT I value at baseline, the value decreased significantly at 30 min after administration in both the left and right eyes. In pigs treated with medetomidine, an artificial tear solution or ophthalmic gel should be applied to protect the ocular surface. The Japanese Society of Veterinary Science 2019-02-08 2019-04 /pmc/articles/PMC6483924/ /pubmed/30745521 http://dx.doi.org/10.1292/jvms.18-0660 Text en ©2019 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: http://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Surgery
KANDA, Teppei
KAJIYAMA, Ayumu
MORIMITSU, Waka
NISHINO, Yukiko
OISHI, Yutaro
SHIMIZU, Yuki
MAETA, Noritaka
FURUMOTO, Kayo
ITOH, Yoshiki
FURUKAWA, Toshinori
Effect of medetomidine on tear flow measured by Schirmer tear test I in normal pigs
title Effect of medetomidine on tear flow measured by Schirmer tear test I in normal pigs
title_full Effect of medetomidine on tear flow measured by Schirmer tear test I in normal pigs
title_fullStr Effect of medetomidine on tear flow measured by Schirmer tear test I in normal pigs
title_full_unstemmed Effect of medetomidine on tear flow measured by Schirmer tear test I in normal pigs
title_short Effect of medetomidine on tear flow measured by Schirmer tear test I in normal pigs
title_sort effect of medetomidine on tear flow measured by schirmer tear test i in normal pigs
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483924/
https://www.ncbi.nlm.nih.gov/pubmed/30745521
http://dx.doi.org/10.1292/jvms.18-0660
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