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Eeyarestatin Compounds Selectively Enhance Sec61-Mediated Ca(2+) Leakage from the Endoplasmic Reticulum

Eeyarestatin 1 (ES1) inhibits p97-dependent protein degradation, Sec61-dependent protein translocation into the endoplasmic reticulum (ER), and vesicular transport within the endomembrane system. Here, we show that ES1 impairs Ca(2+) homeostasis by enhancing the Ca(2+) leakage from mammalian ER. A c...

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Detalles Bibliográficos
Autores principales:	Gamayun, Igor, O'Keefe, Sarah, Pick, Tillman, Klein, Marie-Christine, Nguyen, Duy, McKibbin, Craig, Piacenti, Michela, Williams, Helen M., Flitsch, Sabine L., Whitehead, Roger C., Swanton, Eileithyia, Helms, Volkhard, High, Stephen, Zimmermann, Richard, Cavalié, Adolfo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483976/ https://www.ncbi.nlm.nih.gov/pubmed/30799222 http://dx.doi.org/10.1016/j.chembiol.2019.01.010

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