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The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair

The chromosome 21 encoded protein kinase DYRK1A is essential for normal human development. Mutations in DYRK1A underlie a spectrum of human developmental disorders, and increased dosage in trisomy 21 is implicated in Down syndrome related pathologies. DYRK1A regulates a diverse array of cellular pro...

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Detalles Bibliográficos
Autores principales:	Guard, Steven E., Poss, Zachary C., Ebmeier, Christopher C., Pagratis, Maria, Simpson, Helen, Taatjes, Dylan J., Old, William M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483993/ https://www.ncbi.nlm.nih.gov/pubmed/31024071 http://dx.doi.org/10.1038/s41598-019-42990-5

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