Epigenetic drug library screening identified an LSD1 inhibitor to target UTX-deficient cells for differentiation therapy

UTX (also known as KDM6A), a histone 3 lysine 27 demethylase, is among the most frequently mutated epigenetic regulators in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Recent studies have suggested that UTX mutations promote MDS and AML by blocking the differentiation of hematop...

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Detalles Bibliográficos
Autores principales: Wu, Baohong, Pan, Xiangyu, Chen, Xuelan, Chen, Mei, Shi, Kaidou, Xu, Jing, Zheng, Jianan, Niu, Ting, Chen, Chong, Shuai, Xiao, Liu, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483994/
https://www.ncbi.nlm.nih.gov/pubmed/31044091
http://dx.doi.org/10.1038/s41392-019-0040-2

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