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Molecular basis of cullin-3 (Cul3) ubiquitin ligase subversion by vaccinia virus protein A55

BTB–Kelch proteins are substrate-specific adaptors for cullin-3 (Cul3) RING-box–based E3 ubiquitin ligases, mediating protein ubiquitylation for subsequent proteasomal degradation. Vaccinia virus encodes three BTB–Kelch proteins: A55, C2, and F3. Viruses lacking A55 or C2 have altered cytopathic eff...

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Detalles Bibliográficos
Autores principales:	Gao, Chen, Pallett, Mitchell A., Croll, Tristan I., Smith, Geoffrey L., Graham, Stephen C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2019
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484134/ https://www.ncbi.nlm.nih.gov/pubmed/30819806 http://dx.doi.org/10.1074/jbc.RA118.006561

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