Central nervous system post-transplant lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation: The Nagasaki transplant group experience

A 17-year-old male received allogeneic transplantation for acute lymphoblastic leukemia, and presented with generalized seizures due to a solitary brain lesion with massive necrosis on day +621. Epstein–Barr virus (EBV) DNA copies were below the cut-off value in plasma. Stereotactic biopsy of the ce...

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Detalles Bibliográficos
Autores principales: Sakamoto, Hikaru, Itonaga, Hidehiro, Taguchi, Jun, Kato, Takeharu, Sawayama, Yasushi, Hayashi, Tomayoshi, Baba, Shiro, Moriuchi, Masako, Ohshima, Koichi, Yoshida, Shinichiro, Moriuchi, Yukiyoshi, Miyazaki, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484211/
https://www.ncbi.nlm.nih.gov/pubmed/31049285
http://dx.doi.org/10.1016/j.lrr.2019.04.003
Descripción
Sumario:A 17-year-old male received allogeneic transplantation for acute lymphoblastic leukemia, and presented with generalized seizures due to a solitary brain lesion with massive necrosis on day +621. Epstein–Barr virus (EBV) DNA copies were below the cut-off value in plasma. Stereotactic biopsy of the cerebral lesion confirmed the diagnosis of post-transplant lymphoproliferative disorder (PTLD) with large atypical cells positive for CD20 and EBER. In order to diagnose primary central nervous system PTLD, the biopsy should be applied as early as possible when brain lesion with necrosis develops in post-transplant patients regardless of EBV-DNA in plasma.

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