Central nervous system post-transplant lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation: The Nagasaki transplant group experience

A 17-year-old male received allogeneic transplantation for acute lymphoblastic leukemia, and presented with generalized seizures due to a solitary brain lesion with massive necrosis on day +621. Epstein–Barr virus (EBV) DNA copies were below the cut-off value in plasma. Stereotactic biopsy of the ce...

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Autores principales: Sakamoto, Hikaru, Itonaga, Hidehiro, Taguchi, Jun, Kato, Takeharu, Sawayama, Yasushi, Hayashi, Tomayoshi, Baba, Shiro, Moriuchi, Masako, Ohshima, Koichi, Yoshida, Shinichiro, Moriuchi, Yukiyoshi, Miyazaki, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484211/
https://www.ncbi.nlm.nih.gov/pubmed/31049285
http://dx.doi.org/10.1016/j.lrr.2019.04.003
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author Sakamoto, Hikaru
Itonaga, Hidehiro
Taguchi, Jun
Kato, Takeharu
Sawayama, Yasushi
Hayashi, Tomayoshi
Baba, Shiro
Moriuchi, Masako
Ohshima, Koichi
Yoshida, Shinichiro
Moriuchi, Yukiyoshi
Miyazaki, Yasushi
author_facet Sakamoto, Hikaru
Itonaga, Hidehiro
Taguchi, Jun
Kato, Takeharu
Sawayama, Yasushi
Hayashi, Tomayoshi
Baba, Shiro
Moriuchi, Masako
Ohshima, Koichi
Yoshida, Shinichiro
Moriuchi, Yukiyoshi
Miyazaki, Yasushi
author_sort Sakamoto, Hikaru
collection PubMed
description A 17-year-old male received allogeneic transplantation for acute lymphoblastic leukemia, and presented with generalized seizures due to a solitary brain lesion with massive necrosis on day +621. Epstein–Barr virus (EBV) DNA copies were below the cut-off value in plasma. Stereotactic biopsy of the cerebral lesion confirmed the diagnosis of post-transplant lymphoproliferative disorder (PTLD) with large atypical cells positive for CD20 and EBER. In order to diagnose primary central nervous system PTLD, the biopsy should be applied as early as possible when brain lesion with necrosis develops in post-transplant patients regardless of EBV-DNA in plasma.
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spelling pubmed-64842112019-05-02 Central nervous system post-transplant lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation: The Nagasaki transplant group experience Sakamoto, Hikaru Itonaga, Hidehiro Taguchi, Jun Kato, Takeharu Sawayama, Yasushi Hayashi, Tomayoshi Baba, Shiro Moriuchi, Masako Ohshima, Koichi Yoshida, Shinichiro Moriuchi, Yukiyoshi Miyazaki, Yasushi Leuk Res Rep Article A 17-year-old male received allogeneic transplantation for acute lymphoblastic leukemia, and presented with generalized seizures due to a solitary brain lesion with massive necrosis on day +621. Epstein–Barr virus (EBV) DNA copies were below the cut-off value in plasma. Stereotactic biopsy of the cerebral lesion confirmed the diagnosis of post-transplant lymphoproliferative disorder (PTLD) with large atypical cells positive for CD20 and EBER. In order to diagnose primary central nervous system PTLD, the biopsy should be applied as early as possible when brain lesion with necrosis develops in post-transplant patients regardless of EBV-DNA in plasma. Elsevier 2019-04-22 /pmc/articles/PMC6484211/ /pubmed/31049285 http://dx.doi.org/10.1016/j.lrr.2019.04.003 Text en © 2019 The Authors. Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Sakamoto, Hikaru
Itonaga, Hidehiro
Taguchi, Jun
Kato, Takeharu
Sawayama, Yasushi
Hayashi, Tomayoshi
Baba, Shiro
Moriuchi, Masako
Ohshima, Koichi
Yoshida, Shinichiro
Moriuchi, Yukiyoshi
Miyazaki, Yasushi
Central nervous system post-transplant lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation: The Nagasaki transplant group experience
title Central nervous system post-transplant lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation: The Nagasaki transplant group experience
title_full Central nervous system post-transplant lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation: The Nagasaki transplant group experience
title_fullStr Central nervous system post-transplant lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation: The Nagasaki transplant group experience
title_full_unstemmed Central nervous system post-transplant lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation: The Nagasaki transplant group experience
title_short Central nervous system post-transplant lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation: The Nagasaki transplant group experience
title_sort central nervous system post-transplant lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation: the nagasaki transplant group experience
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484211/
https://www.ncbi.nlm.nih.gov/pubmed/31049285
http://dx.doi.org/10.1016/j.lrr.2019.04.003
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