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Atypical functional connectivity between the anterior cingulate cortex and other brain regions in a rat model of recurrent headache

We explored the atypical functional connectivity between the anterior cingulate cortex and other brain areas in rats subjected to repeated meningeal nociception. The rat model was established by infusing an inflammatory soup through supradural catheters in conscious rats. Rats were subdivided accord...

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Autores principales: Jia, Zhihua, Chen, Xiaoyan, Tang, Wenjing, Zhao, Dengfa, Yu, Shengyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484243/
https://www.ncbi.nlm.nih.gov/pubmed/30900511
http://dx.doi.org/10.1177/1744806919842483
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author Jia, Zhihua
Chen, Xiaoyan
Tang, Wenjing
Zhao, Dengfa
Yu, Shengyuan
author_facet Jia, Zhihua
Chen, Xiaoyan
Tang, Wenjing
Zhao, Dengfa
Yu, Shengyuan
author_sort Jia, Zhihua
collection PubMed
description We explored the atypical functional connectivity between the anterior cingulate cortex and other brain areas in rats subjected to repeated meningeal nociception. The rat model was established by infusing an inflammatory soup through supradural catheters in conscious rats. Rats were subdivided according to the frequency of the inflammatory soup infusions. Functional connectivity analysis seeded on the anterior cingulate cortex was performed on rats 21 days after inflammatory soup infusion. Glyceryl trinitrate was injected following baseline scanning in the low-frequency inflammatory soup group and magnetic resonance imaging data were acquired 1 h after the injection. The rats exhibited nociceptive behavior after high-frequency inflammatory soup infusion. The anterior cingulate cortex showed increased functional connectivity with the cerebellum in the inflammatory soup groups. The medulla showed increased functional connectivity with the anterior cingulate cortex in the ictal period in the low-frequency inflammatory soup rats. Several areas showed increased functional connectivity with the anterior cingulate cortex in the high-frequency inflammatory soup group, including the pontine tegmentum, midbrain, thalamus, corpus callosum, hippocampus, and retrosplenial, visual, sensory, and motor cortices. This study indicated that the medulla participates in the early stage of a migraine attack and may be associated with the initiation of migraine. Sensitization of the trigeminal nociceptive pathway might contribute to the cutaneous allodynia seen in chronic migraine. Brain areas important for memory function may be related to the chronification of migraine. Electrophysiological studies should examine those migraine-related areas and provide new targets for migraine treatment and prevention.
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spelling pubmed-64842432019-04-30 Atypical functional connectivity between the anterior cingulate cortex and other brain regions in a rat model of recurrent headache Jia, Zhihua Chen, Xiaoyan Tang, Wenjing Zhao, Dengfa Yu, Shengyuan Mol Pain Research Article We explored the atypical functional connectivity between the anterior cingulate cortex and other brain areas in rats subjected to repeated meningeal nociception. The rat model was established by infusing an inflammatory soup through supradural catheters in conscious rats. Rats were subdivided according to the frequency of the inflammatory soup infusions. Functional connectivity analysis seeded on the anterior cingulate cortex was performed on rats 21 days after inflammatory soup infusion. Glyceryl trinitrate was injected following baseline scanning in the low-frequency inflammatory soup group and magnetic resonance imaging data were acquired 1 h after the injection. The rats exhibited nociceptive behavior after high-frequency inflammatory soup infusion. The anterior cingulate cortex showed increased functional connectivity with the cerebellum in the inflammatory soup groups. The medulla showed increased functional connectivity with the anterior cingulate cortex in the ictal period in the low-frequency inflammatory soup rats. Several areas showed increased functional connectivity with the anterior cingulate cortex in the high-frequency inflammatory soup group, including the pontine tegmentum, midbrain, thalamus, corpus callosum, hippocampus, and retrosplenial, visual, sensory, and motor cortices. This study indicated that the medulla participates in the early stage of a migraine attack and may be associated with the initiation of migraine. Sensitization of the trigeminal nociceptive pathway might contribute to the cutaneous allodynia seen in chronic migraine. Brain areas important for memory function may be related to the chronification of migraine. Electrophysiological studies should examine those migraine-related areas and provide new targets for migraine treatment and prevention. SAGE Publications 2019-04-25 /pmc/articles/PMC6484243/ /pubmed/30900511 http://dx.doi.org/10.1177/1744806919842483 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research Article
Jia, Zhihua
Chen, Xiaoyan
Tang, Wenjing
Zhao, Dengfa
Yu, Shengyuan
Atypical functional connectivity between the anterior cingulate cortex and other brain regions in a rat model of recurrent headache
title Atypical functional connectivity between the anterior cingulate cortex and other brain regions in a rat model of recurrent headache
title_full Atypical functional connectivity between the anterior cingulate cortex and other brain regions in a rat model of recurrent headache
title_fullStr Atypical functional connectivity between the anterior cingulate cortex and other brain regions in a rat model of recurrent headache
title_full_unstemmed Atypical functional connectivity between the anterior cingulate cortex and other brain regions in a rat model of recurrent headache
title_short Atypical functional connectivity between the anterior cingulate cortex and other brain regions in a rat model of recurrent headache
title_sort atypical functional connectivity between the anterior cingulate cortex and other brain regions in a rat model of recurrent headache
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484243/
https://www.ncbi.nlm.nih.gov/pubmed/30900511
http://dx.doi.org/10.1177/1744806919842483
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