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Putative Survival Advantages in Young Apolipoprotein ɛ4 Carriers are Associated with Increased Neural Stress

Inheritance of a single copy of the apolipoprotein E (APOE) ɛ4 allele increases risk of Alzheimer’s disease (AD) by 3-4-fold, with homozygosity associated with a 12-16-fold increase in risk, relative to ɛ3 allele homozygosity. There is a decreased risk associated with the APOE ɛ2 allele. The patholo...

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Detalles Bibliográficos
Autores principales: Smith, Carr J., Ashford, J. Wesson, Perfetti, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484250/
https://www.ncbi.nlm.nih.gov/pubmed/30814349
http://dx.doi.org/10.3233/JAD-181089

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