Acid‐sensing ion channel 1a is involved in ischaemia/reperfusion induced kidney injury by increasing renal epithelia cell apoptosis

Acidic microenvironment is commonly observed in ischaemic tissue. In the kidney, extracellular pH dropped from 7.4 to 6.5 within 10 minutes initiation of ischaemia. Acid‐sensing ion channels (ASICs) can be activated by pH drops from 7.4 to 7.0 or lower and permeates to Ca(2+)entrance. Thus, activati...

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Detalles Bibliográficos
Autores principales: Song, Nana, Lu, Zhihui, Zhang, Jian, Shi, Yiqin, Ning, Yichun, Chen, Jing, Jin, Shi, Shen, Bo, Fang, Yi, Zou, Jianzhou, Teng, Jie, Chu, Xiang-Ping, Shen, Linlin, Ding, Xiaoqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484315/
https://www.ncbi.nlm.nih.gov/pubmed/30793492
http://dx.doi.org/10.1111/jcmm.14238

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