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PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer

Prostate transmembrane protein androgen induced 1 (PMEPA1) has been reported to promote cancer progression. Metastasis is the main factor leading to cancer progression and poor prognosis, and at the beginning of metastasis, epithelial‐to‐mesenchymal transition (EMT) is a crucial activation. However,...

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Detalles Bibliográficos
Autores principales: Zhang, Lei, Wang, Xue, Lai, Chong, Zhang, Honghe, Lai, Maode
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484414/
https://www.ncbi.nlm.nih.gov/pubmed/30887697
http://dx.doi.org/10.1111/jcmm.14261
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author Zhang, Lei
Wang, Xue
Lai, Chong
Zhang, Honghe
Lai, Maode
author_facet Zhang, Lei
Wang, Xue
Lai, Chong
Zhang, Honghe
Lai, Maode
author_sort Zhang, Lei
collection PubMed
description Prostate transmembrane protein androgen induced 1 (PMEPA1) has been reported to promote cancer progression. Metastasis is the main factor leading to cancer progression and poor prognosis, and at the beginning of metastasis, epithelial‐to‐mesenchymal transition (EMT) is a crucial activation. However, the relationship between PMEPA1 and EMT in colorectal cancer metastasis is still poorly understood. In this study, we first testified that PMEPA1 expresses higher in tumour than normal tissue in Gene Expression Omnibus database, in the Cancer Genome Atlas (TCGA) as well as in the clinical data we collected. Moreover, the higher expression was associated with poor prognosis. We furthermore demonstrated PMEPA1 promotes colorectal cancer metastasis and EMT in vivo and in vitro. We found that PMEPA1 activates the bone morphogenetic proteins (BMP) signalling of TGF‐β signalling resulting in promoting EMT and accelerating the proliferation and metastasis of colorectal cancer.
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spelling pubmed-64844142019-05-03 PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer Zhang, Lei Wang, Xue Lai, Chong Zhang, Honghe Lai, Maode J Cell Mol Med Original Articles Prostate transmembrane protein androgen induced 1 (PMEPA1) has been reported to promote cancer progression. Metastasis is the main factor leading to cancer progression and poor prognosis, and at the beginning of metastasis, epithelial‐to‐mesenchymal transition (EMT) is a crucial activation. However, the relationship between PMEPA1 and EMT in colorectal cancer metastasis is still poorly understood. In this study, we first testified that PMEPA1 expresses higher in tumour than normal tissue in Gene Expression Omnibus database, in the Cancer Genome Atlas (TCGA) as well as in the clinical data we collected. Moreover, the higher expression was associated with poor prognosis. We furthermore demonstrated PMEPA1 promotes colorectal cancer metastasis and EMT in vivo and in vitro. We found that PMEPA1 activates the bone morphogenetic proteins (BMP) signalling of TGF‐β signalling resulting in promoting EMT and accelerating the proliferation and metastasis of colorectal cancer. John Wiley and Sons Inc. 2019-03-19 2019-05 /pmc/articles/PMC6484414/ /pubmed/30887697 http://dx.doi.org/10.1111/jcmm.14261 Text en © 2019 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Zhang, Lei
Wang, Xue
Lai, Chong
Zhang, Honghe
Lai, Maode
PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer
title PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer
title_full PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer
title_fullStr PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer
title_full_unstemmed PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer
title_short PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer
title_sort pmepa1 induces emt via a non‐canonical tgf‐β signalling in colorectal cancer
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484414/
https://www.ncbi.nlm.nih.gov/pubmed/30887697
http://dx.doi.org/10.1111/jcmm.14261
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