The prominent impairment of liver/intestinal cytochrome P450 and intestinal drug transporters in sepsis-induced acute kidney injury over acute and chronic renal ischemia, a mouse model comparison

Drug dosing adjustment in sepsis-induced acute kidney injury (sepsis-AKI) is currently adjusted based on renal function. Sepsis is a multiorgan injury, and thus, drug metabolism in sepsis-AKI might be interfered by non-renal factors such as changes in functions of drug-metabolizing enzymes in the li...

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Detalles Bibliográficos
Autores principales: Sukkummee, Warumphon, Jittisak, Patcharin, Wonganan, Piyanuch, Wittayalertpanya, Supeecha, Chariyavilaskul, Pajaree, Leelahavanichkul, Asada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Laboratory Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484470/
https://www.ncbi.nlm.nih.gov/pubmed/30991873
http://dx.doi.org/10.1080/0886022X.2019.1602054

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