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Long-term Outcomes of Endovascular and Open Repair for Traumatic Thoracic Aortic Injury

IMPORTANCE: Thoracic endovascular aortic repair (TEVAR) has been adopted rapidly for treating traumatic thoracic aortic injury (TAI). The long-term durability and efficacy remain unknown. OBJECTIVE: To determine the long-term outcomes of thoracic endovascular aortic repair and those of open repair (...

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Autores principales: Cheng, Yu-Ting, Cheng, Chi-Tung, Wang, Shang-Yu, Wu, Victor Chien-Chia, Chu, Pao-Hsien, Chou, An-Hsun, Chen, Ching-Chang, Ko, Po-Jen, Liu, Kuo-Sheng, Chen, Shao-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484615/
https://www.ncbi.nlm.nih.gov/pubmed/30735232
http://dx.doi.org/10.1001/jamanetworkopen.2018.7861
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author Cheng, Yu-Ting
Cheng, Chi-Tung
Wang, Shang-Yu
Wu, Victor Chien-Chia
Chu, Pao-Hsien
Chou, An-Hsun
Chen, Ching-Chang
Ko, Po-Jen
Liu, Kuo-Sheng
Chen, Shao-Wei
author_facet Cheng, Yu-Ting
Cheng, Chi-Tung
Wang, Shang-Yu
Wu, Victor Chien-Chia
Chu, Pao-Hsien
Chou, An-Hsun
Chen, Ching-Chang
Ko, Po-Jen
Liu, Kuo-Sheng
Chen, Shao-Wei
author_sort Cheng, Yu-Ting
collection PubMed
description IMPORTANCE: Thoracic endovascular aortic repair (TEVAR) has been adopted rapidly for treating traumatic thoracic aortic injury (TAI). The long-term durability and efficacy remain unknown. OBJECTIVE: To determine the long-term outcomes of thoracic endovascular aortic repair and those of open repair (OR) for traumatic TAI. DESIGN, SETTING, PARTICIPANTS: This nationwide cohort study used Taiwan’s National Health Insurance Database to evaluate patients with traumatic TAI between January 1, 2004, and December 31, 2013. This single-payer National Health Insurance program covered more than 99.9% of the Taiwanese population. Those who received OR or TEVAR for TAI by propensity score matching were included. Data analysis was conducted in October 2017. EXPOSURES: Thoracic endovascular aortic repair vs open repair. MAIN OUTCOMES AND MEASURES: In-hospital outcomes, all-cause mortality, aorta reintervention, and stroke during follow-up. RESULTS: Of the 287 patients (mean [SD] age, 41.66 [17.98] years; 80.5% male) who received OR or TEVAR for TAI, propensity score matching yielded 100 patients each in the OR and TEVAR groups. After propensity score matching, in-hospital mortality risk was significantly lower in the TEVAR group (9 [9.0%]) than in the OR group (27 [27.0%]; TEVAR vs open repair: odds ratio, 0.27; 95% CI, 0.12-0.60). With a mean (SD) follow-up of 2.80 (2.63) years, the proportion of survivors was 71.9% at 1 year, 70.8% at 2 years, 68.2% at 3 years, and 65.1% at 5 years in the OR group vs 88.9% at 1 year, 88.9% at 2 years, 88.9% at 3 years, and 88.9% at 5 years in the TEVAR group (log-rank test, P < .001). The TEVAR group had only 2 events (2%) of late reintervention and 1 event (1%) of late cerebrovascular accident. The proportion of freedom from reintervention was 100% at 1 year, 100% at 2 years, 100% at 3 years, and 100% at 5 years in the OR group vs 97.4% at 1 year, 97.4% at 2 years, 97.4% at 3 years, and 97.4% at 5 years in the TEVAR group (log-rank test, P = .18). CONCLUSION AND RELEVANCE: Compared with OR, TEVAR was associated with better long-term outcomes, mainly owing to lower mortality during the perioperative period. In addition, TEVAR was associated with a similar rate of survival and reintervention after hospital discharge.
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spelling pubmed-64846152019-05-21 Long-term Outcomes of Endovascular and Open Repair for Traumatic Thoracic Aortic Injury Cheng, Yu-Ting Cheng, Chi-Tung Wang, Shang-Yu Wu, Victor Chien-Chia Chu, Pao-Hsien Chou, An-Hsun Chen, Ching-Chang Ko, Po-Jen Liu, Kuo-Sheng Chen, Shao-Wei JAMA Netw Open Original Investigation IMPORTANCE: Thoracic endovascular aortic repair (TEVAR) has been adopted rapidly for treating traumatic thoracic aortic injury (TAI). The long-term durability and efficacy remain unknown. OBJECTIVE: To determine the long-term outcomes of thoracic endovascular aortic repair and those of open repair (OR) for traumatic TAI. DESIGN, SETTING, PARTICIPANTS: This nationwide cohort study used Taiwan’s National Health Insurance Database to evaluate patients with traumatic TAI between January 1, 2004, and December 31, 2013. This single-payer National Health Insurance program covered more than 99.9% of the Taiwanese population. Those who received OR or TEVAR for TAI by propensity score matching were included. Data analysis was conducted in October 2017. EXPOSURES: Thoracic endovascular aortic repair vs open repair. MAIN OUTCOMES AND MEASURES: In-hospital outcomes, all-cause mortality, aorta reintervention, and stroke during follow-up. RESULTS: Of the 287 patients (mean [SD] age, 41.66 [17.98] years; 80.5% male) who received OR or TEVAR for TAI, propensity score matching yielded 100 patients each in the OR and TEVAR groups. After propensity score matching, in-hospital mortality risk was significantly lower in the TEVAR group (9 [9.0%]) than in the OR group (27 [27.0%]; TEVAR vs open repair: odds ratio, 0.27; 95% CI, 0.12-0.60). With a mean (SD) follow-up of 2.80 (2.63) years, the proportion of survivors was 71.9% at 1 year, 70.8% at 2 years, 68.2% at 3 years, and 65.1% at 5 years in the OR group vs 88.9% at 1 year, 88.9% at 2 years, 88.9% at 3 years, and 88.9% at 5 years in the TEVAR group (log-rank test, P < .001). The TEVAR group had only 2 events (2%) of late reintervention and 1 event (1%) of late cerebrovascular accident. The proportion of freedom from reintervention was 100% at 1 year, 100% at 2 years, 100% at 3 years, and 100% at 5 years in the OR group vs 97.4% at 1 year, 97.4% at 2 years, 97.4% at 3 years, and 97.4% at 5 years in the TEVAR group (log-rank test, P = .18). CONCLUSION AND RELEVANCE: Compared with OR, TEVAR was associated with better long-term outcomes, mainly owing to lower mortality during the perioperative period. In addition, TEVAR was associated with a similar rate of survival and reintervention after hospital discharge. American Medical Association 2019-02-08 /pmc/articles/PMC6484615/ /pubmed/30735232 http://dx.doi.org/10.1001/jamanetworkopen.2018.7861 Text en Copyright 2019 Cheng Y-T et al. JAMA Network Open. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the CC-BY License.
spellingShingle Original Investigation
Cheng, Yu-Ting
Cheng, Chi-Tung
Wang, Shang-Yu
Wu, Victor Chien-Chia
Chu, Pao-Hsien
Chou, An-Hsun
Chen, Ching-Chang
Ko, Po-Jen
Liu, Kuo-Sheng
Chen, Shao-Wei
Long-term Outcomes of Endovascular and Open Repair for Traumatic Thoracic Aortic Injury
title Long-term Outcomes of Endovascular and Open Repair for Traumatic Thoracic Aortic Injury
title_full Long-term Outcomes of Endovascular and Open Repair for Traumatic Thoracic Aortic Injury
title_fullStr Long-term Outcomes of Endovascular and Open Repair for Traumatic Thoracic Aortic Injury
title_full_unstemmed Long-term Outcomes of Endovascular and Open Repair for Traumatic Thoracic Aortic Injury
title_short Long-term Outcomes of Endovascular and Open Repair for Traumatic Thoracic Aortic Injury
title_sort long-term outcomes of endovascular and open repair for traumatic thoracic aortic injury
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484615/
https://www.ncbi.nlm.nih.gov/pubmed/30735232
http://dx.doi.org/10.1001/jamanetworkopen.2018.7861
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