Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2

Tumor recurrence is attributable to cancer stem-like cells (CSCs), the metabolic mechanisms of which currently remain obscure. Here, we uncovered the critical role of folate-mediated one-carbon (1C) metabolism involving mitochondrial methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) and its downstr...

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Detalles Bibliográficos
Autores principales: Nishimura, Tatsunori, Nakata, Asuka, Chen, Xiaoxi, Nishi, Kurumi, Meguro-Horike, Makiko, Sasaki, Soichiro, Kita, Kenji, Horike, Shin-ichi, Saitoh, Kaori, Kato, Keiko, Igarashi, Kaori, Murayama, Takahiko, Kohno, Susumu, Takahashi, Chiaki, Mukaida, Naofumi, Yano, Seiji, Soga, Tomoyoshi, Tojo, Arinobu, Gotoh, Noriko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484769/
https://www.ncbi.nlm.nih.gov/pubmed/30532069
http://dx.doi.org/10.1038/s41388-018-0589-1

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