Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation

AMPK acts downstream of the tumor suppressor LKB1, yet its role in cancer has been controversial. AMPK is activated by biguanides, such as metformin and phenformin, and metformin use in diabetics has been associated with reduced cancer risk. However, whether this is mediated by cell-autonomous AMPK...

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Detalles Bibliográficos
Autores principales: Vara-Ciruelos, Diana, Dandapani, Madhumita, Russell, Fiona M., Grzes, Katarzyna M., Atrih, Abdelmadjid, Foretz, Marc, Viollet, Benoit, Lamont, Douglas J., Cantrell, Doreen A., Hardie, D. Grahame
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484776/
https://www.ncbi.nlm.nih.gov/pubmed/30995468
http://dx.doi.org/10.1016/j.celrep.2019.03.067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484776/
https://www.ncbi.nlm.nih.gov/pubmed/30995468
http://dx.doi.org/10.1016/j.celrep.2019.03.067

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