Cargando…

Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation

AMPK acts downstream of the tumor suppressor LKB1, yet its role in cancer has been controversial. AMPK is activated by biguanides, such as metformin and phenformin, and metformin use in diabetics has been associated with reduced cancer risk. However, whether this is mediated by cell-autonomous AMPK...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vara-Ciruelos, Diana, Dandapani, Madhumita, Russell, Fiona M., Grzes, Katarzyna M., Atrih, Abdelmadjid, Foretz, Marc, Viollet, Benoit, Lamont, Douglas J., Cantrell, Doreen A., Hardie, D. Grahame
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484776/ https://www.ncbi.nlm.nih.gov/pubmed/30995468 http://dx.doi.org/10.1016/j.celrep.2019.03.067

Ejemplares similares

Mechanism of Activation of AMPK by Cordycepin
por: Hawley, Simon A., et al.
Publicado: (2020)

Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib
por: Ross, Fiona A., et al.
Publicado: (2017)

The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde?(†)
por: Vara-Ciruelos, Diana, et al.
Publicado: (2019)

Adenosine-Mono-Phosphate-Activated Protein Kinase-Independent Effects of Metformin in T Cells
por: Zarrouk, Marouan, et al.
Publicado: (2014)

AMPKα1: A glucose sensor that controls CD8 T-cell memory
por: Rolf, Julia, et al.
Publicado: (2013)

A Comparative Study of the Lipophilicity of Metformin and Phenformin
por: Dołowy, Małgorzata, et al.
Publicado: (2021)

AMPK is not required for the effect of metformin on the inhibition of BMP6-induced hepcidin gene expression in hepatocytes
por: Deschemin, Jean-Christophe, et al.
Publicado: (2017)

Aldolase is a sensor for both low and high glucose, linking to AMPK and mTORC1
por: Li, Mengqi, et al.
Publicado: (2020)

Destabilization of MYC/MYCN by the mitochondrial inhibitors, metaiodobenzylguanidine, metformin and phenformin
por: WANG, STEPHANIE S., et al.
Publicado: (2014)

Activation of AMPK for a Break in Hepatic Lipid Accumulation and Circulating Cholesterol
por: Foretz, Marc, et al.
Publicado: (2018)

Phenformin and metformin inhibit growth and migration of LN229 glioma cells in vitro and in vivo
por: Wang, Yanmin, et al.
Publicado: (2018)

Metformin: update on mechanisms of action and repurposing potential
por: Foretz, Marc, et al.
Publicado: (2023)

Defining the Contribution of AMP-activated Protein Kinase (AMPK) and Protein Kinase C (PKC) in Regulation of Glucose Uptake by Metformin in Skeletal Muscle Cells
por: Turban, Sophie, et al.
Publicado: (2012)

Effects of metformin and phenformin on apoptosis and epithelial‐mesenchymal transition in chemoresistant rectal cancer
por: Park, Ji‐Hye, et al.
Publicado: (2019)

Phenformin alone or combined with gefitinib inhibits bladder cancer via AMPK and EGFR pathways
por: Huang, Yanjun, et al.
Publicado: (2018)

AMPK – roles in nutrient sensing and in cancer
por: Hardie, D Grahame
Publicado: (2014)

Caspase cleavage and nuclear retention of the energy sensor AMPK-α1 during apoptosis
por: Cheratta, Anees Rahman, et al.
Publicado: (2022)

AMPK and SNF1: Snuffing Out Stress
por: Hardie, D. Grahame
Publicado: (2007)

AMPK Activation Reduces Hepatic Lipid Content by Increasing Fat Oxidation In Vivo
por: Foretz, Marc, et al.
Publicado: (2018)

Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis
por: LaMoia, Traci E., et al.
Publicado: (2022)

Combination of metformin and phenformin synergistically inhibits proliferation and hTERT expression in human breast cancer cells
por: Jafari-Gharabaghlou, Davoud, et al.
Publicado: (2018)

AMPK - a nutrient and energy sensor with roles in diabetes, cancer and viral infection
por: Hardie, Grahame
Publicado: (2012)

Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK
por: Hunter, Roger W., et al.
Publicado: (2014)

The antitumor properties of metformin and phenformin reflect their ability to inhibit the actions of differentiated embryo chondrocyte 1
por: Kuo, Chun-Lin, et al.
Publicado: (2019)

AMPK integrates metabolite and kinase-based immunometabolic control in macrophages
por: Phair, Iain R., et al.
Publicado: (2022)

AMPK Activation Promotes Tight Junction Assembly in Intestinal Epithelial Caco-2 Cells
por: Olivier, Séverine, et al.
Publicado: (2019)

AMPK: A Target for Drugs and Natural Products With Effects on Both Diabetes and Cancer
por: Hardie, D. Grahame
Publicado: (2013)

Obesity Impairs Skeletal Muscle Regeneration Through Inhibition of AMPK
por: Fu, Xing, et al.
Publicado: (2016)

Phenformin as an Anticancer Agent: Challenges and Prospects
por: García Rubiño, Mª Eugenia, et al.
Publicado: (2019)

The mechanisms of action of metformin
por: Rena, Graham, et al.
Publicado: (2017)

AMPK and the Need to Breathe and Feed: What’s the Matter with Oxygen?
por: Evans, A. Mark, et al.
Publicado: (2020)

Comparison of Effects of Metformin, Phenformin, and Inhibitors of Mitochondrial Complex I on Mitochondrial Permeability Transition and Ischemic Brain Injury
por: Skemiene, Kristina, et al.
Publicado: (2020)

LKB1 and AMPK and the cancer-metabolism link - ten years after
por: Hardie, D Grahame, et al.
Publicado: (2013)

AMPK promotes lysosomal and mitochondrial biogenesis via folliculin:FNIP1
por: Freemantle, Jordana B, et al.
Publicado: (2023)

AMPK: Regulating Energy Balance at the Cellular and Whole Body Levels
por: Hardie, D. Grahame, et al.
Publicado: (2014)

Phenformin as prophylaxis and therapy in breast cancer xenografts
por: Appleyard, M V C L, et al.
Publicado: (2012)

Synergistic Anti-Cancer Effect of Phenformin and Oxamate
por: Miskimins, W. Keith, et al.
Publicado: (2014)

AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development
por: Boudaba, Nadia, et al.
Publicado: (2018)

Repurposing phenformin for the targeting of glioma stem cells and the treatment of glioblastoma
por: Jiang, Wei, et al.
Publicado: (2016)

Metformin Induces Apoptosis through AMPK-Dependent Inhibition of UPR Signaling in ALL Lymphoblasts
por: Leclerc, Gilles M., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_o4u38mm8451rbs9qt0l79dh2u9