Visual Experience Regulates the Intrinsic Excitability of Visual Cortical Neurons to Maintain Sensory Function

This in vivo study shows that both intrinsic and sensory-evoked synaptic properties of layer 2/3 neurons in mouse visual cortex are modified by ongoing visual input. Following visual deprivation, intrinsic properties are significantly altered, although orientation selectivity across the population r...

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Detalles Bibliográficos
Autores principales: Brown, Alexander P.Y., Cossell, Lee, Margrie, Troy W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484778/
https://www.ncbi.nlm.nih.gov/pubmed/30995467
http://dx.doi.org/10.1016/j.celrep.2019.03.073
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author Brown, Alexander P.Y.
Cossell, Lee
Margrie, Troy W.
author_facet Brown, Alexander P.Y.
Cossell, Lee
Margrie, Troy W.
author_sort Brown, Alexander P.Y.
collection PubMed
description This in vivo study shows that both intrinsic and sensory-evoked synaptic properties of layer 2/3 neurons in mouse visual cortex are modified by ongoing visual input. Following visual deprivation, intrinsic properties are significantly altered, although orientation selectivity across the population remains unchanged. We, therefore, suggest that cortical cells adjust their intrinsic excitability in an activity-dependent manner to compensate for changes in synaptic drive and maintain sensory network function.
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spelling pubmed-64847782019-04-26 Visual Experience Regulates the Intrinsic Excitability of Visual Cortical Neurons to Maintain Sensory Function Brown, Alexander P.Y. Cossell, Lee Margrie, Troy W. Cell Rep Article This in vivo study shows that both intrinsic and sensory-evoked synaptic properties of layer 2/3 neurons in mouse visual cortex are modified by ongoing visual input. Following visual deprivation, intrinsic properties are significantly altered, although orientation selectivity across the population remains unchanged. We, therefore, suggest that cortical cells adjust their intrinsic excitability in an activity-dependent manner to compensate for changes in synaptic drive and maintain sensory network function. Cell Press 2019-04-16 /pmc/articles/PMC6484778/ /pubmed/30995467 http://dx.doi.org/10.1016/j.celrep.2019.03.073 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Brown, Alexander P.Y.
Cossell, Lee
Margrie, Troy W.
Visual Experience Regulates the Intrinsic Excitability of Visual Cortical Neurons to Maintain Sensory Function
title Visual Experience Regulates the Intrinsic Excitability of Visual Cortical Neurons to Maintain Sensory Function
title_full Visual Experience Regulates the Intrinsic Excitability of Visual Cortical Neurons to Maintain Sensory Function
title_fullStr Visual Experience Regulates the Intrinsic Excitability of Visual Cortical Neurons to Maintain Sensory Function
title_full_unstemmed Visual Experience Regulates the Intrinsic Excitability of Visual Cortical Neurons to Maintain Sensory Function
title_short Visual Experience Regulates the Intrinsic Excitability of Visual Cortical Neurons to Maintain Sensory Function
title_sort visual experience regulates the intrinsic excitability of visual cortical neurons to maintain sensory function
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484778/
https://www.ncbi.nlm.nih.gov/pubmed/30995467
http://dx.doi.org/10.1016/j.celrep.2019.03.073
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AT margrietroyw visualexperienceregulatestheintrinsicexcitabilityofvisualcorticalneuronstomaintainsensoryfunction

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