Staphylococcal peptidoglycans induce arthritis

Staphylococcus aureus is one of the most important pathogens in septic arthritis. To analyse the arthritogenic properties of staphylococcal peptidoglycan (PGN), highly purified PGN from S. aureus was intra-articularly injected into murine joints. The results demonstrate that PGN will trigger arthrit...

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Autores principales: Liu, Zai-Qing, Deng, Guo-Min, Foster, Simon, Tarkowski, Andrej
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC64849/
https://www.ncbi.nlm.nih.gov/pubmed/11714392
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author Liu, Zai-Qing
Deng, Guo-Min
Foster, Simon
Tarkowski, Andrej
author_facet Liu, Zai-Qing
Deng, Guo-Min
Foster, Simon
Tarkowski, Andrej
author_sort Liu, Zai-Qing
collection PubMed
description Staphylococcus aureus is one of the most important pathogens in septic arthritis. To analyse the arthritogenic properties of staphylococcal peptidoglycan (PGN), highly purified PGN from S. aureus was intra-articularly injected into murine joints. The results demonstrate that PGN will trigger arthritis in a dose-dependent manner. A single injection of this compound leads to massive infiltration of predominantly macrophages and polymorphonuclear cells with occasional signs of cartilage and/or bone destruction, lasting for at least 14 days. Further studies showed that this condition is mediated by the combined impact of acquired and innate immune systems. Our results indicate that PGN exerts a central role in joint inflammation triggered by S. aureus.
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spelling pubmed-648492002-01-25 Staphylococcal peptidoglycans induce arthritis Liu, Zai-Qing Deng, Guo-Min Foster, Simon Tarkowski, Andrej Arthritis Res Research Article Staphylococcus aureus is one of the most important pathogens in septic arthritis. To analyse the arthritogenic properties of staphylococcal peptidoglycan (PGN), highly purified PGN from S. aureus was intra-articularly injected into murine joints. The results demonstrate that PGN will trigger arthritis in a dose-dependent manner. A single injection of this compound leads to massive infiltration of predominantly macrophages and polymorphonuclear cells with occasional signs of cartilage and/or bone destruction, lasting for at least 14 days. Further studies showed that this condition is mediated by the combined impact of acquired and innate immune systems. Our results indicate that PGN exerts a central role in joint inflammation triggered by S. aureus. BioMed Central 2001 2001-09-17 /pmc/articles/PMC64849/ /pubmed/11714392 Text en Copyright © 2001 Liu et al, licensee BioMed Central Ltd
spellingShingle Research Article
Liu, Zai-Qing
Deng, Guo-Min
Foster, Simon
Tarkowski, Andrej
Staphylococcal peptidoglycans induce arthritis
title Staphylococcal peptidoglycans induce arthritis
title_full Staphylococcal peptidoglycans induce arthritis
title_fullStr Staphylococcal peptidoglycans induce arthritis
title_full_unstemmed Staphylococcal peptidoglycans induce arthritis
title_short Staphylococcal peptidoglycans induce arthritis
title_sort staphylococcal peptidoglycans induce arthritis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC64849/
https://www.ncbi.nlm.nih.gov/pubmed/11714392
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