Staphylococcal peptidoglycans induce arthritis
Staphylococcus aureus is one of the most important pathogens in septic arthritis. To analyse the arthritogenic properties of staphylococcal peptidoglycan (PGN), highly purified PGN from S. aureus was intra-articularly injected into murine joints. The results demonstrate that PGN will trigger arthrit...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2001
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC64849/ https://www.ncbi.nlm.nih.gov/pubmed/11714392 |
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author | Liu, Zai-Qing Deng, Guo-Min Foster, Simon Tarkowski, Andrej |
author_facet | Liu, Zai-Qing Deng, Guo-Min Foster, Simon Tarkowski, Andrej |
author_sort | Liu, Zai-Qing |
collection | PubMed |
description | Staphylococcus aureus is one of the most important pathogens in septic arthritis. To analyse the arthritogenic properties of staphylococcal peptidoglycan (PGN), highly purified PGN from S. aureus was intra-articularly injected into murine joints. The results demonstrate that PGN will trigger arthritis in a dose-dependent manner. A single injection of this compound leads to massive infiltration of predominantly macrophages and polymorphonuclear cells with occasional signs of cartilage and/or bone destruction, lasting for at least 14 days. Further studies showed that this condition is mediated by the combined impact of acquired and innate immune systems. Our results indicate that PGN exerts a central role in joint inflammation triggered by S. aureus. |
format | Text |
id | pubmed-64849 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2001 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-648492002-01-25 Staphylococcal peptidoglycans induce arthritis Liu, Zai-Qing Deng, Guo-Min Foster, Simon Tarkowski, Andrej Arthritis Res Research Article Staphylococcus aureus is one of the most important pathogens in septic arthritis. To analyse the arthritogenic properties of staphylococcal peptidoglycan (PGN), highly purified PGN from S. aureus was intra-articularly injected into murine joints. The results demonstrate that PGN will trigger arthritis in a dose-dependent manner. A single injection of this compound leads to massive infiltration of predominantly macrophages and polymorphonuclear cells with occasional signs of cartilage and/or bone destruction, lasting for at least 14 days. Further studies showed that this condition is mediated by the combined impact of acquired and innate immune systems. Our results indicate that PGN exerts a central role in joint inflammation triggered by S. aureus. BioMed Central 2001 2001-09-17 /pmc/articles/PMC64849/ /pubmed/11714392 Text en Copyright © 2001 Liu et al, licensee BioMed Central Ltd |
spellingShingle | Research Article Liu, Zai-Qing Deng, Guo-Min Foster, Simon Tarkowski, Andrej Staphylococcal peptidoglycans induce arthritis |
title | Staphylococcal peptidoglycans induce arthritis |
title_full | Staphylococcal peptidoglycans induce arthritis |
title_fullStr | Staphylococcal peptidoglycans induce arthritis |
title_full_unstemmed | Staphylococcal peptidoglycans induce arthritis |
title_short | Staphylococcal peptidoglycans induce arthritis |
title_sort | staphylococcal peptidoglycans induce arthritis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC64849/ https://www.ncbi.nlm.nih.gov/pubmed/11714392 |
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