Cargando…

Serum FGF21 Levels in Obese Korean Children and Adolescents

BACKGROUND: Serum fibroblast growth factor 21 (FGF21) has been suggested to be a possible biomarker for early detection of metabolic syndrome and type 2 diabetes in adults. However, few studies have investigated the correlation between FGF21 levels and metabolic parameters in children. This study so...

Descripción completa

Detalles Bibliográficos
Autores principales: Baek, Joonwoo, Nam, Hyo-Kyoung, Rhie, Young-Jun, Lee, Kee-Hyoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for the Study of Obesity 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484916/
https://www.ncbi.nlm.nih.gov/pubmed/31089518
http://dx.doi.org/10.7570/jomes.2017.26.3.204
_version_ 1783414186202628096
author Baek, Joonwoo
Nam, Hyo-Kyoung
Rhie, Young-Jun
Lee, Kee-Hyoung
author_facet Baek, Joonwoo
Nam, Hyo-Kyoung
Rhie, Young-Jun
Lee, Kee-Hyoung
author_sort Baek, Joonwoo
collection PubMed
description BACKGROUND: Serum fibroblast growth factor 21 (FGF21) has been suggested to be a possible biomarker for early detection of metabolic syndrome and type 2 diabetes in adults. However, few studies have investigated the correlation between FGF21 levels and metabolic parameters in children. This study sought to evaluate the relationship between FGF21 and metabolic parameters in obese Korean children and adolescents. METHODS: Fasting serum FGF21 and adiponectin levels as well as fasting insulin, glucose, transaminases, and lipid profiles were measured by enzyme-linked immunosorbent assays in 45 lean and 70 obese children aged 7–14 years. Independent t-test and multivariate correlation analysis were used to evaluate the relationship between FGF21 and metabolic parameters. RESULTS: Serum FGF21 was significantly higher in obese children than in lean children. Serum FGF21 levels were positively correlated with insulin resistance index homeostasis model assessment (HOMA-IR) (r=0.355, P=0.004) and triglycerides (r=0.423, P<0.001) and were negatively correlated with high-density lipoprotein (HDL) cholesterol (r=−0.412, P<0.001). After adjustment for body mass index, triglycerides, HDL cholesterol and adiponectin, FGF21 levels showed a significant correlation with only HOMA-IR on multivariate linear regression analysis. CONCLUSION: Serum FGF21 levels were higher in obese children and significantly correlated with HOMA-IR. Therefore, FGF21 could be a biomarker for obesity-induced insulin resistance in children and adolescents as indicated in adults.
format Online
Article
Text
id pubmed-6484916
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Korean Society for the Study of Obesity
record_format MEDLINE/PubMed
spelling pubmed-64849162019-05-14 Serum FGF21 Levels in Obese Korean Children and Adolescents Baek, Joonwoo Nam, Hyo-Kyoung Rhie, Young-Jun Lee, Kee-Hyoung J Obes Metab Syndr Original Article BACKGROUND: Serum fibroblast growth factor 21 (FGF21) has been suggested to be a possible biomarker for early detection of metabolic syndrome and type 2 diabetes in adults. However, few studies have investigated the correlation between FGF21 levels and metabolic parameters in children. This study sought to evaluate the relationship between FGF21 and metabolic parameters in obese Korean children and adolescents. METHODS: Fasting serum FGF21 and adiponectin levels as well as fasting insulin, glucose, transaminases, and lipid profiles were measured by enzyme-linked immunosorbent assays in 45 lean and 70 obese children aged 7–14 years. Independent t-test and multivariate correlation analysis were used to evaluate the relationship between FGF21 and metabolic parameters. RESULTS: Serum FGF21 was significantly higher in obese children than in lean children. Serum FGF21 levels were positively correlated with insulin resistance index homeostasis model assessment (HOMA-IR) (r=0.355, P=0.004) and triglycerides (r=0.423, P<0.001) and were negatively correlated with high-density lipoprotein (HDL) cholesterol (r=−0.412, P<0.001). After adjustment for body mass index, triglycerides, HDL cholesterol and adiponectin, FGF21 levels showed a significant correlation with only HOMA-IR on multivariate linear regression analysis. CONCLUSION: Serum FGF21 levels were higher in obese children and significantly correlated with HOMA-IR. Therefore, FGF21 could be a biomarker for obesity-induced insulin resistance in children and adolescents as indicated in adults. Korean Society for the Study of Obesity 2017-09 2017-09-30 /pmc/articles/PMC6484916/ /pubmed/31089518 http://dx.doi.org/10.7570/jomes.2017.26.3.204 Text en Copyright © 2017 Korean Society for the Study of Obesity This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Baek, Joonwoo
Nam, Hyo-Kyoung
Rhie, Young-Jun
Lee, Kee-Hyoung
Serum FGF21 Levels in Obese Korean Children and Adolescents
title Serum FGF21 Levels in Obese Korean Children and Adolescents
title_full Serum FGF21 Levels in Obese Korean Children and Adolescents
title_fullStr Serum FGF21 Levels in Obese Korean Children and Adolescents
title_full_unstemmed Serum FGF21 Levels in Obese Korean Children and Adolescents
title_short Serum FGF21 Levels in Obese Korean Children and Adolescents
title_sort serum fgf21 levels in obese korean children and adolescents
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484916/
https://www.ncbi.nlm.nih.gov/pubmed/31089518
http://dx.doi.org/10.7570/jomes.2017.26.3.204
work_keys_str_mv AT baekjoonwoo serumfgf21levelsinobesekoreanchildrenandadolescents
AT namhyokyoung serumfgf21levelsinobesekoreanchildrenandadolescents
AT rhieyoungjun serumfgf21levelsinobesekoreanchildrenandadolescents
AT leekeehyoung serumfgf21levelsinobesekoreanchildrenandadolescents