Synbiotic Supplementation May Relieve Anterior Uveitis, an Ocular Manifestation in Behcet’s Syndrome

Patient: Female, 49 Final Diagnosis: Behcet’s syndrome (with anterior uveitis) Symptoms: Ocular problems: redness • tearing • severe pain • photophobia • blurred vision Medication: Synbiotic supplementation Clinical Procedure: — Specialty: Nutrition and Dietetics OBJECTIVE: Rare disease BACKGROUND: To relieve the signs and symptoms of anterior uveitis (AU), an ocular manifestation of Behcet’s syndrome, we prescribed a synbiotic supplementation (probiotics and prebiotics) for a 49-year-old woman. CASE REPORT: Seven strains of bacteria – Lactobacillus casei, Lactobacillus rhamnosus, Streptococcus thermophilus, Bifidobacterium breve, Lactobacillus acidophilus, Bifidobacterium longum, and Lactobacillus bulgaricus, each 10(8) colony-forming units (CFU) – and fructo-oligosaccharide (FOS; 100 mg) were given as a capsule 2 times per day. After 7-month treatment, AU was improved and serum inflammatory markers – C-reactive protein (CRP), high-sensitivity CRP (hs-CRP), and estimated sedimentation rate (ESR) – were suppressed. Now, if a mild AU attack occurs, the problem is resolved by treatment with 1 gtt (from the Latin “guttae”, meaning drops) eye drop (prednisolone 1%) for 1 week. CONCLUSIONS: Synbiotic supplementation may contribute to treating AU, which is one of the most disastrous manifestations of BS, by controlling the proinflammatory processes.