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Fn14 overcomes cisplatin resistance of high-grade serous ovarian cancer by promoting Mdm2-mediated p53-R248Q ubiquitination and degradation

BACKGROUND: High-grade serous ovarian cancer (HGSOC) is the most lethal of all gynecological malignancies. Patients often suffer from chemoresistance. Several studies have reported that Fn14 could regulate migration, invasion, and angiogenesis in cancer cells. However, its functional role in chemore...

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Detalles Bibliográficos
Autores principales:	Wu, An-Yue, Gu, Li-Ying, Cang, Wei, Cheng, Meng-Xing, Wang, Wen-Jing, Di, Wen, Huang, Lei, Qiu, Li-Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485139/ https://www.ncbi.nlm.nih.gov/pubmed/31023317 http://dx.doi.org/10.1186/s13046-019-1171-6

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