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The role of the gut microbiome in sex differences in arterial pressure

There has been intense interest in the role of the gut microbiome in human health and a broad range of diseases in recent years. In the context of cardiovascular disease, gut dysbiosis (defined as a change in the gut microbiome and the gut-epithelial barrier) has been linked to disturbances in blood...

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Detalles Bibliográficos
Autores principales: Beale, Anna L., Kaye, David M., Marques, Francine Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485140/
https://www.ncbi.nlm.nih.gov/pubmed/31023366
http://dx.doi.org/10.1186/s13293-019-0236-8
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author Beale, Anna L.
Kaye, David M.
Marques, Francine Z.
author_facet Beale, Anna L.
Kaye, David M.
Marques, Francine Z.
author_sort Beale, Anna L.
collection PubMed
description There has been intense interest in the role of the gut microbiome in human health and a broad range of diseases in recent years. In the context of cardiovascular disease, gut dysbiosis (defined as a change in the gut microbiome and the gut-epithelial barrier) has been linked to disturbances in blood pressure (BP) regulation. These findings build upon our understanding of the complex pathophysiology of essential hypertension. There are clear sex differences in the epidemiology of hypertension, with distinct trends in BP across the life-course in men and women. To date, a role for the gut microbiome in contributing to the sex differences in BP is yet to be clearly established. The purpose of this review is to summarise the current literature regarding how the gut microbiome differs between men and women and to investigate whether sex-determined differences in the gut microbiome influence the response to factors such as diet, obesity and inflammation. Finally, we will explore evidence for the possible interaction between sex-specific factors, including sex hormones and pregnancy, with the gut in the context of hypertension pathophysiology.
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spelling pubmed-64851402019-05-03 The role of the gut microbiome in sex differences in arterial pressure Beale, Anna L. Kaye, David M. Marques, Francine Z. Biol Sex Differ Review There has been intense interest in the role of the gut microbiome in human health and a broad range of diseases in recent years. In the context of cardiovascular disease, gut dysbiosis (defined as a change in the gut microbiome and the gut-epithelial barrier) has been linked to disturbances in blood pressure (BP) regulation. These findings build upon our understanding of the complex pathophysiology of essential hypertension. There are clear sex differences in the epidemiology of hypertension, with distinct trends in BP across the life-course in men and women. To date, a role for the gut microbiome in contributing to the sex differences in BP is yet to be clearly established. The purpose of this review is to summarise the current literature regarding how the gut microbiome differs between men and women and to investigate whether sex-determined differences in the gut microbiome influence the response to factors such as diet, obesity and inflammation. Finally, we will explore evidence for the possible interaction between sex-specific factors, including sex hormones and pregnancy, with the gut in the context of hypertension pathophysiology. BioMed Central 2019-04-25 /pmc/articles/PMC6485140/ /pubmed/31023366 http://dx.doi.org/10.1186/s13293-019-0236-8 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Beale, Anna L.
Kaye, David M.
Marques, Francine Z.
The role of the gut microbiome in sex differences in arterial pressure
title The role of the gut microbiome in sex differences in arterial pressure
title_full The role of the gut microbiome in sex differences in arterial pressure
title_fullStr The role of the gut microbiome in sex differences in arterial pressure
title_full_unstemmed The role of the gut microbiome in sex differences in arterial pressure
title_short The role of the gut microbiome in sex differences in arterial pressure
title_sort role of the gut microbiome in sex differences in arterial pressure
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485140/
https://www.ncbi.nlm.nih.gov/pubmed/31023366
http://dx.doi.org/10.1186/s13293-019-0236-8
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