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Brevibacterium paucivorans bacteremia: case report and review of the literature
BACKGROUND: Brevibacteria are obligate aerobic gram-positive rods that are associated with milk products and are also found on human skin. Brevibacterium has been reported as a rare cause of catheter related blood steam infection mainly in immunocompromised hosts such as malignancies or AIDS patient...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485150/ https://www.ncbi.nlm.nih.gov/pubmed/31023246 http://dx.doi.org/10.1186/s12879-019-3962-y |
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author | Asai, Nobuhiro Suematsu, Hiroyuki Yamada, Atsuko Watanabe, Hiroki Nishiyama, Naoya Sakanashi, Daisuke Kato, Hideo Shiota, Arufumi Hagihara, Mao Koizumi, Yusuke Yamagishi, Yuka Mikamo, Hiroshige |
author_facet | Asai, Nobuhiro Suematsu, Hiroyuki Yamada, Atsuko Watanabe, Hiroki Nishiyama, Naoya Sakanashi, Daisuke Kato, Hideo Shiota, Arufumi Hagihara, Mao Koizumi, Yusuke Yamagishi, Yuka Mikamo, Hiroshige |
author_sort | Asai, Nobuhiro |
collection | PubMed |
description | BACKGROUND: Brevibacteria are obligate aerobic gram-positive rods that are associated with milk products and are also found on human skin. Brevibacterium has been reported as a rare cause of catheter related blood steam infection mainly in immunocompromised hosts such as malignancies or AIDS patients. CASE PRESENTATION: A 94-year old woman, which had a past history of diabetes mellitus and chronic heart failure, presented with high fever associated with decreased oral intake and appetite loss and was admitted to our institute. A physical examination at the time of presentation was unremarkable. On day 2, both blood cultures collected on admission became positive with coryneform organism within 24 h without Staphylococci and Brevibacterium species were identified by Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Subsequently, genetic investigation by 16S ribosomal RNA analysis was performed in order to identify the organism. Finally, the result identified this pathogen as Brevibacterium paucivorans with 99.5% homology on the Ez taxon database. The patient was started empirically on meropenem and teicoplanin for broad-spectrum antibiotic coverage. The patient’s fever finally abated and labs were also improved. On day 14, the antibiotic therapy was discontinued. The site of infections was unknown. We hereby report a case of Brevibacterium paicivorans bacteremia in an immunocompetent patient and review cases of Brevibacterium specises bacteremia previously reported. This is the first case of B. paucivorans bacteremia as far as we could search. CONCLUSION: Physicians and microbiologists should be aware that Brevibacteria are uncommon but important agents which could cause opportunistic infections in immunocompetent. |
format | Online Article Text |
id | pubmed-6485150 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-64851502019-05-03 Brevibacterium paucivorans bacteremia: case report and review of the literature Asai, Nobuhiro Suematsu, Hiroyuki Yamada, Atsuko Watanabe, Hiroki Nishiyama, Naoya Sakanashi, Daisuke Kato, Hideo Shiota, Arufumi Hagihara, Mao Koizumi, Yusuke Yamagishi, Yuka Mikamo, Hiroshige BMC Infect Dis Case Report BACKGROUND: Brevibacteria are obligate aerobic gram-positive rods that are associated with milk products and are also found on human skin. Brevibacterium has been reported as a rare cause of catheter related blood steam infection mainly in immunocompromised hosts such as malignancies or AIDS patients. CASE PRESENTATION: A 94-year old woman, which had a past history of diabetes mellitus and chronic heart failure, presented with high fever associated with decreased oral intake and appetite loss and was admitted to our institute. A physical examination at the time of presentation was unremarkable. On day 2, both blood cultures collected on admission became positive with coryneform organism within 24 h without Staphylococci and Brevibacterium species were identified by Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Subsequently, genetic investigation by 16S ribosomal RNA analysis was performed in order to identify the organism. Finally, the result identified this pathogen as Brevibacterium paucivorans with 99.5% homology on the Ez taxon database. The patient was started empirically on meropenem and teicoplanin for broad-spectrum antibiotic coverage. The patient’s fever finally abated and labs were also improved. On day 14, the antibiotic therapy was discontinued. The site of infections was unknown. We hereby report a case of Brevibacterium paicivorans bacteremia in an immunocompetent patient and review cases of Brevibacterium specises bacteremia previously reported. This is the first case of B. paucivorans bacteremia as far as we could search. CONCLUSION: Physicians and microbiologists should be aware that Brevibacteria are uncommon but important agents which could cause opportunistic infections in immunocompetent. BioMed Central 2019-04-25 /pmc/articles/PMC6485150/ /pubmed/31023246 http://dx.doi.org/10.1186/s12879-019-3962-y Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Asai, Nobuhiro Suematsu, Hiroyuki Yamada, Atsuko Watanabe, Hiroki Nishiyama, Naoya Sakanashi, Daisuke Kato, Hideo Shiota, Arufumi Hagihara, Mao Koizumi, Yusuke Yamagishi, Yuka Mikamo, Hiroshige Brevibacterium paucivorans bacteremia: case report and review of the literature |
title | Brevibacterium paucivorans bacteremia: case report and review of the literature |
title_full | Brevibacterium paucivorans bacteremia: case report and review of the literature |
title_fullStr | Brevibacterium paucivorans bacteremia: case report and review of the literature |
title_full_unstemmed | Brevibacterium paucivorans bacteremia: case report and review of the literature |
title_short | Brevibacterium paucivorans bacteremia: case report and review of the literature |
title_sort | brevibacterium paucivorans bacteremia: case report and review of the literature |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485150/ https://www.ncbi.nlm.nih.gov/pubmed/31023246 http://dx.doi.org/10.1186/s12879-019-3962-y |
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