Nano-Structural Effects on Gene Transfection: Large, Botryoid-Shaped Nanoparticles Enhance DNA Delivery via Macropinocytosis and Effective Dissociation

Effective delivery is the primary barrier against the clinical translation of gene therapy. Yet there remains too much unknown in the gene delivery mechanisms, even for the most investigated polymeric carrier (i.e., PEI). As a consequence, the conflicting results have been often seen in the literatu...

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Detalles Bibliográficos
Autores principales: Zhang, Wenyuan, Kang, Xuejia, Yuan, Bo, Wang, Huiyuan, Zhang, Tao, Shi, Mingjie, Zheng, Zening, Zhang, Yuanheng, Peng, Chengyuan, Fan, Xiaoming, Yang, Huaiyu, Shen, Youqing, Huang, Yongzhuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485200/
https://www.ncbi.nlm.nih.gov/pubmed/31037125
http://dx.doi.org/10.7150/thno.30302

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