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High c-Myb Expression Associates with Good Prognosis in Colorectal Carcinoma

Colorectal cancer (CRC) represents a serious challenge for oncologists due to high incidence and large heterogeneity. Prognostic factors are needed to stratify patients according to risk of disease progression. In this study, we report that high expression of c-Myb protein, determined by immunohisto...

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Detalles Bibliográficos
Autores principales: Tichý, Michal, Knopfová, Lucia, Jarkovský, Jiří, Vlček, Petr, Katolická, Jana, Čapov, Ivan, Hermanová, Markéta, Šmarda, Jan, Beneš, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485226/
https://www.ncbi.nlm.nih.gov/pubmed/31031849
http://dx.doi.org/10.7150/jca.29530
Descripción
Sumario:Colorectal cancer (CRC) represents a serious challenge for oncologists due to high incidence and large heterogeneity. Prognostic factors are needed to stratify patients according to risk of disease progression. In this study, we report that high expression of c-Myb protein, determined by immunohistochemistry (IHC), associates with better overall and disease-free survival (OS, DFS) in a cohort of 103 patients. Although MYB has been previously considered to act as oncogene in CRC, our further analysis of datasets deposited in PrognoScan and SurvExpress databases confirmed that high MYB expression largely associates with good prognosis in CRC. As therapies targeting c-Myb have been developed and tested in preclinical studies, we believe that further studies are needed for detailed understanding of c-Myb function in CRC, before the c-Myb-targeted therapy enters clinical trials.