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High c-Myb Expression Associates with Good Prognosis in Colorectal Carcinoma

Colorectal cancer (CRC) represents a serious challenge for oncologists due to high incidence and large heterogeneity. Prognostic factors are needed to stratify patients according to risk of disease progression. In this study, we report that high expression of c-Myb protein, determined by immunohisto...

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Autores principales: Tichý, Michal, Knopfová, Lucia, Jarkovský, Jiří, Vlček, Petr, Katolická, Jana, Čapov, Ivan, Hermanová, Markéta, Šmarda, Jan, Beneš, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485226/
https://www.ncbi.nlm.nih.gov/pubmed/31031849
http://dx.doi.org/10.7150/jca.29530
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author Tichý, Michal
Knopfová, Lucia
Jarkovský, Jiří
Vlček, Petr
Katolická, Jana
Čapov, Ivan
Hermanová, Markéta
Šmarda, Jan
Beneš, Petr
author_facet Tichý, Michal
Knopfová, Lucia
Jarkovský, Jiří
Vlček, Petr
Katolická, Jana
Čapov, Ivan
Hermanová, Markéta
Šmarda, Jan
Beneš, Petr
author_sort Tichý, Michal
collection PubMed
description Colorectal cancer (CRC) represents a serious challenge for oncologists due to high incidence and large heterogeneity. Prognostic factors are needed to stratify patients according to risk of disease progression. In this study, we report that high expression of c-Myb protein, determined by immunohistochemistry (IHC), associates with better overall and disease-free survival (OS, DFS) in a cohort of 103 patients. Although MYB has been previously considered to act as oncogene in CRC, our further analysis of datasets deposited in PrognoScan and SurvExpress databases confirmed that high MYB expression largely associates with good prognosis in CRC. As therapies targeting c-Myb have been developed and tested in preclinical studies, we believe that further studies are needed for detailed understanding of c-Myb function in CRC, before the c-Myb-targeted therapy enters clinical trials.
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spelling pubmed-64852262019-04-26 High c-Myb Expression Associates with Good Prognosis in Colorectal Carcinoma Tichý, Michal Knopfová, Lucia Jarkovský, Jiří Vlček, Petr Katolická, Jana Čapov, Ivan Hermanová, Markéta Šmarda, Jan Beneš, Petr J Cancer Short Research Communication Colorectal cancer (CRC) represents a serious challenge for oncologists due to high incidence and large heterogeneity. Prognostic factors are needed to stratify patients according to risk of disease progression. In this study, we report that high expression of c-Myb protein, determined by immunohistochemistry (IHC), associates with better overall and disease-free survival (OS, DFS) in a cohort of 103 patients. Although MYB has been previously considered to act as oncogene in CRC, our further analysis of datasets deposited in PrognoScan and SurvExpress databases confirmed that high MYB expression largely associates with good prognosis in CRC. As therapies targeting c-Myb have been developed and tested in preclinical studies, we believe that further studies are needed for detailed understanding of c-Myb function in CRC, before the c-Myb-targeted therapy enters clinical trials. Ivyspring International Publisher 2019-02-23 /pmc/articles/PMC6485226/ /pubmed/31031849 http://dx.doi.org/10.7150/jca.29530 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Short Research Communication
Tichý, Michal
Knopfová, Lucia
Jarkovský, Jiří
Vlček, Petr
Katolická, Jana
Čapov, Ivan
Hermanová, Markéta
Šmarda, Jan
Beneš, Petr
High c-Myb Expression Associates with Good Prognosis in Colorectal Carcinoma
title High c-Myb Expression Associates with Good Prognosis in Colorectal Carcinoma
title_full High c-Myb Expression Associates with Good Prognosis in Colorectal Carcinoma
title_fullStr High c-Myb Expression Associates with Good Prognosis in Colorectal Carcinoma
title_full_unstemmed High c-Myb Expression Associates with Good Prognosis in Colorectal Carcinoma
title_short High c-Myb Expression Associates with Good Prognosis in Colorectal Carcinoma
title_sort high c-myb expression associates with good prognosis in colorectal carcinoma
topic Short Research Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485226/
https://www.ncbi.nlm.nih.gov/pubmed/31031849
http://dx.doi.org/10.7150/jca.29530
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