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Nanotechnology in metastatic cancer treatment: Current Achievements and Future Research Trends

The systemic spread of malignant cells from a primary site, a process termed metastasis represents a global challenge in cancer treatment. There is a real need to develop novel therapy strategies and nanomedicine may have remarkable and valuable contribution through specific and selective delivery o...

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Detalles Bibliográficos
Autores principales: Gonciar, Diana, Mocan, Teodora, Matea, Cristian Tudor, Zdrehus, Claudiu, Mosteanu, Ofelia, Mocan, Lucian, Pop, Teodora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485233/
https://www.ncbi.nlm.nih.gov/pubmed/31031845
http://dx.doi.org/10.7150/jca.28394
Descripción
Sumario:The systemic spread of malignant cells from a primary site, a process termed metastasis represents a global challenge in cancer treatment. There is a real need to develop novel therapy strategies and nanomedicine may have remarkable and valuable contribution through specific and selective delivery of chemotherapeutic agents, through its intrinsic cytotoxic activity or through imaging applications, appealing also in the context of cancer personalized therapy. This review is focused on the applications of nanoparticles in the treatment of metastatic cancer, particularly on the possible effect on cell stabilization, growth inhibition, eventual interaction with adhesion molecules and antiangiogenic effect.