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Prognostic impact of family history of cancer in Southern Chinese patients with esophageal squamous cell cancer

Background: First degree family history of cancer is associated with developing esophageal cancer and sparse data is about the impact on poor survival among established esophageal squamous cell cancer (ESCC) patients. In this study, we investigated the prognoses of patients with ESCC with a family h...

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Autores principales: Su, Zhen, Zou, Guo-Rong, Mao, Yan-Ping, OuYang, Pu-Yun, Cao, Xiao-Long, Xie, Fang-Yun, Li, Qun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485237/
https://www.ncbi.nlm.nih.gov/pubmed/31031844
http://dx.doi.org/10.7150/jca.26511
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author Su, Zhen
Zou, Guo-Rong
Mao, Yan-Ping
OuYang, Pu-Yun
Cao, Xiao-Long
Xie, Fang-Yun
Li, Qun
author_facet Su, Zhen
Zou, Guo-Rong
Mao, Yan-Ping
OuYang, Pu-Yun
Cao, Xiao-Long
Xie, Fang-Yun
Li, Qun
author_sort Su, Zhen
collection PubMed
description Background: First degree family history of cancer is associated with developing esophageal cancer and sparse data is about the impact on poor survival among established esophageal squamous cell cancer (ESCC) patients. In this study, we investigated the prognoses of patients with ESCC with a family history. Methods: A total of 479 ESCC patients were retrospectively enrolled from a Southern Chinese institution. A positive family history was defined as having malignant cancer among parents and siblings. Kaplan-Meier plots and Cox proportional hazards regressions were applied for overall survival (OS) and progression-free survival (PFS). Results: Among 479 patients, 119 (24.8%) and 68 (14.2%) reported a first-degree family history of cancer and digestive tract cancer, respectively. Compared with patients without a family history of cancer, the adjusted hazard ratios (HR) among those with it were 1.40 (95% CI, 1.08-1.82, p=0.011) for death, 1.36 (95% CI, 1.05-1.76, p=0.018) for progression. Similar results were observed in those with a family history of digestive tract cancer (HR=1.69, 95%CI, 1.24-1.98, p=0.001 for death and HR=1.77, 95%CI, 1.30-2.37, p<0.001 for progression, respectively). Furthermore, there was a trend for increasing risk of overall mortality (p=0.021, p=0.004, respectively), and progression (p=0.022, p=0.001, respectively) with an increasing number of affected family members. Conclusion: A first-degree family history of cancer, especially digestive tract cancer is associated with poor survival for established ESCC patients and plays an important role in prognosis. The patients with a family history of cancer might need a greater intensity of treatment and more frequent follow-up.
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spelling pubmed-64852372019-04-26 Prognostic impact of family history of cancer in Southern Chinese patients with esophageal squamous cell cancer Su, Zhen Zou, Guo-Rong Mao, Yan-Ping OuYang, Pu-Yun Cao, Xiao-Long Xie, Fang-Yun Li, Qun J Cancer Research Paper Background: First degree family history of cancer is associated with developing esophageal cancer and sparse data is about the impact on poor survival among established esophageal squamous cell cancer (ESCC) patients. In this study, we investigated the prognoses of patients with ESCC with a family history. Methods: A total of 479 ESCC patients were retrospectively enrolled from a Southern Chinese institution. A positive family history was defined as having malignant cancer among parents and siblings. Kaplan-Meier plots and Cox proportional hazards regressions were applied for overall survival (OS) and progression-free survival (PFS). Results: Among 479 patients, 119 (24.8%) and 68 (14.2%) reported a first-degree family history of cancer and digestive tract cancer, respectively. Compared with patients without a family history of cancer, the adjusted hazard ratios (HR) among those with it were 1.40 (95% CI, 1.08-1.82, p=0.011) for death, 1.36 (95% CI, 1.05-1.76, p=0.018) for progression. Similar results were observed in those with a family history of digestive tract cancer (HR=1.69, 95%CI, 1.24-1.98, p=0.001 for death and HR=1.77, 95%CI, 1.30-2.37, p<0.001 for progression, respectively). Furthermore, there was a trend for increasing risk of overall mortality (p=0.021, p=0.004, respectively), and progression (p=0.022, p=0.001, respectively) with an increasing number of affected family members. Conclusion: A first-degree family history of cancer, especially digestive tract cancer is associated with poor survival for established ESCC patients and plays an important role in prognosis. The patients with a family history of cancer might need a greater intensity of treatment and more frequent follow-up. Ivyspring International Publisher 2019-02-07 /pmc/articles/PMC6485237/ /pubmed/31031844 http://dx.doi.org/10.7150/jca.26511 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Su, Zhen
Zou, Guo-Rong
Mao, Yan-Ping
OuYang, Pu-Yun
Cao, Xiao-Long
Xie, Fang-Yun
Li, Qun
Prognostic impact of family history of cancer in Southern Chinese patients with esophageal squamous cell cancer
title Prognostic impact of family history of cancer in Southern Chinese patients with esophageal squamous cell cancer
title_full Prognostic impact of family history of cancer in Southern Chinese patients with esophageal squamous cell cancer
title_fullStr Prognostic impact of family history of cancer in Southern Chinese patients with esophageal squamous cell cancer
title_full_unstemmed Prognostic impact of family history of cancer in Southern Chinese patients with esophageal squamous cell cancer
title_short Prognostic impact of family history of cancer in Southern Chinese patients with esophageal squamous cell cancer
title_sort prognostic impact of family history of cancer in southern chinese patients with esophageal squamous cell cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485237/
https://www.ncbi.nlm.nih.gov/pubmed/31031844
http://dx.doi.org/10.7150/jca.26511
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