CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons

Mutations of the cyclin-dependent kinase like 5 (CDKL5) and netrin-G1 (NTNG1) genes cause a severe neurodevelopmental disorder with clinical features that are closely related to Rett syndrome (RTT), including intellectual disability, early onset intractable epilepsy and autism. We report here that C...

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Detalles Bibliográficos
Autores principales: Ricciardi, Sara, Ungaro, Federica, Hambrock, Melanie, Rademacher, Nils, Stefanelli, Gilda, Brambilla, Dario, Sessa, Alessandro, Magagnotti, Cinzia, Bachi, Angela, Giarda, Elisa, Verpelli, Chiara, Kilstrup-Nielsen, Charlotte, Sala, Carlo, Kalscheuer, Vera M., Broccoli, Vania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485419/
https://www.ncbi.nlm.nih.gov/pubmed/22922712
http://dx.doi.org/10.1038/ncb2566

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