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Incidence and Risk Factors for Bone Metastasis in Non-Small Cell Lung Cancer

BACKGROUND: Bone is a frequent site of metastasis from various primary cancers including with Non-Small Cell Lung Cancer. The aim of this study was to investigate the incidence and risk factors for Bone Metastasis in patients with Non-Small Cell Lung Cancer. METHODOLOGY: A cohort study was carried o...

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Autores principales: da Silva, Gustavo Telles, Bergmann, Anke, Thuler, Luiz Claudio Santos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485556/
https://www.ncbi.nlm.nih.gov/pubmed/30678379
http://dx.doi.org/10.31557/APJCP.2019.20.1.45
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author da Silva, Gustavo Telles
Bergmann, Anke
Thuler, Luiz Claudio Santos
author_facet da Silva, Gustavo Telles
Bergmann, Anke
Thuler, Luiz Claudio Santos
author_sort da Silva, Gustavo Telles
collection PubMed
description BACKGROUND: Bone is a frequent site of metastasis from various primary cancers including with Non-Small Cell Lung Cancer. The aim of this study was to investigate the incidence and risk factors for Bone Metastasis in patients with Non-Small Cell Lung Cancer. METHODOLOGY: A cohort study was carried out in patients diagnosed with Non-Small Cell Lung Cancer between 2006 and 2014 in a single cancer centre. A descriptive analysis of the population was compiled based on mean ± standard deviation (SD) for continuous variables and percentage (%) for categorical variables. Univariate and multivariate Cox proportional hazards regression analyses were carried out to quantify the relationship between independent variables and the outcome variable (Bone Metastasis). RESULTS: During the study period 1025 patients were diagnosed with Non-Small Cell Lung Cancer. Bone Metastasis was detected in 136 patients (13.2%) with a mean interval between Non-Small Cell Lung Cancer diagnosis and Bone Metastasis of 8.07 months (95% CI: 7.68 8.45). Multivariate analysis revealed that younger age (HR 0.97; 95%CI, 0.95–0.99; p=0.002), adenocarcinoma (HR 1.51; 95%CI, 1.06–2.15; p=0.021) and treatment with chemotherapy, radiotherapy or chemotherapy combined with radiotherapy (HR 3.73; 95%CI, 2.30–6.05; p<0.001) were associated with the occurrence of Bone Metastasis. CONCLUSION: The incidence of Bone Metastasis was 13.2%. Younger age, histological subtype adenocarcinoma and treatment with chemotherapy, radiotherapy or chemotherapy combined with radiotherapy are independent risk factors for Bone Metastasis.
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spelling pubmed-64855562019-05-13 Incidence and Risk Factors for Bone Metastasis in Non-Small Cell Lung Cancer da Silva, Gustavo Telles Bergmann, Anke Thuler, Luiz Claudio Santos Asian Pac J Cancer Prev Research Article BACKGROUND: Bone is a frequent site of metastasis from various primary cancers including with Non-Small Cell Lung Cancer. The aim of this study was to investigate the incidence and risk factors for Bone Metastasis in patients with Non-Small Cell Lung Cancer. METHODOLOGY: A cohort study was carried out in patients diagnosed with Non-Small Cell Lung Cancer between 2006 and 2014 in a single cancer centre. A descriptive analysis of the population was compiled based on mean ± standard deviation (SD) for continuous variables and percentage (%) for categorical variables. Univariate and multivariate Cox proportional hazards regression analyses were carried out to quantify the relationship between independent variables and the outcome variable (Bone Metastasis). RESULTS: During the study period 1025 patients were diagnosed with Non-Small Cell Lung Cancer. Bone Metastasis was detected in 136 patients (13.2%) with a mean interval between Non-Small Cell Lung Cancer diagnosis and Bone Metastasis of 8.07 months (95% CI: 7.68 8.45). Multivariate analysis revealed that younger age (HR 0.97; 95%CI, 0.95–0.99; p=0.002), adenocarcinoma (HR 1.51; 95%CI, 1.06–2.15; p=0.021) and treatment with chemotherapy, radiotherapy or chemotherapy combined with radiotherapy (HR 3.73; 95%CI, 2.30–6.05; p<0.001) were associated with the occurrence of Bone Metastasis. CONCLUSION: The incidence of Bone Metastasis was 13.2%. Younger age, histological subtype adenocarcinoma and treatment with chemotherapy, radiotherapy or chemotherapy combined with radiotherapy are independent risk factors for Bone Metastasis. West Asia Organization for Cancer Prevention 2019 /pmc/articles/PMC6485556/ /pubmed/30678379 http://dx.doi.org/10.31557/APJCP.2019.20.1.45 Text en Copyright: © Asian Pacific Journal of Cancer Prevention http://creativecommons.org/licenses/BY-SA/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
spellingShingle Research Article
da Silva, Gustavo Telles
Bergmann, Anke
Thuler, Luiz Claudio Santos
Incidence and Risk Factors for Bone Metastasis in Non-Small Cell Lung Cancer
title Incidence and Risk Factors for Bone Metastasis in Non-Small Cell Lung Cancer
title_full Incidence and Risk Factors for Bone Metastasis in Non-Small Cell Lung Cancer
title_fullStr Incidence and Risk Factors for Bone Metastasis in Non-Small Cell Lung Cancer
title_full_unstemmed Incidence and Risk Factors for Bone Metastasis in Non-Small Cell Lung Cancer
title_short Incidence and Risk Factors for Bone Metastasis in Non-Small Cell Lung Cancer
title_sort incidence and risk factors for bone metastasis in non-small cell lung cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485556/
https://www.ncbi.nlm.nih.gov/pubmed/30678379
http://dx.doi.org/10.31557/APJCP.2019.20.1.45
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