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Immunohistochemical Evaluation of Ki-67 and Comparison with Clinicopathologic Factors in Breast Carcinomas

BACKGROUND: Patients primarily received tamoxifen based on their menopausal status due to the lack of immunohistochemistry. A recent study has shown that hormonal receptors were not correlated with menopausal status, and thus, indicating that they present limited therapeutic and prognostic significa...

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Autores principales: Aman, Nguiessan Alphonse, Doukoure, Brahima, Koffi, Kouadio Donatien, Koui, Baumaney Sylvanus, Traore, Zie Cheick, Kouyate, Mohamed, Toure, Ibrahiman, Effi, Ahoua Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485584/
https://www.ncbi.nlm.nih.gov/pubmed/30678383
http://dx.doi.org/10.31557/APJCP.2019.20.1.73
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author Aman, Nguiessan Alphonse
Doukoure, Brahima
Koffi, Kouadio Donatien
Koui, Baumaney Sylvanus
Traore, Zie Cheick
Kouyate, Mohamed
Toure, Ibrahiman
Effi, Ahoua Benjamin
author_facet Aman, Nguiessan Alphonse
Doukoure, Brahima
Koffi, Kouadio Donatien
Koui, Baumaney Sylvanus
Traore, Zie Cheick
Kouyate, Mohamed
Toure, Ibrahiman
Effi, Ahoua Benjamin
author_sort Aman, Nguiessan Alphonse
collection PubMed
description BACKGROUND: Patients primarily received tamoxifen based on their menopausal status due to the lack of immunohistochemistry. A recent study has shown that hormonal receptors were not correlated with menopausal status, and thus, indicating that they present limited therapeutic and prognostic significance in breast cancer management. This study aimed to evaluate Ki-67 value and analyze its association with clinicopathologic parameters in breast cancer patients. METHODS: The formalin-fixed paraffin-embedded breast tissue blocks of 125 patients with primary breast carcinomas were subjected to immunohistochemical analysis using Ventana Benchmark(®) GX automated immunostainer. Analysis of variance and Chi-2 test were used to examine the relationship between Ki-67 and clinicopathologic variables. RESULTS: The mean age of 125 patients included in the study was 47.7 years. The average score of Ki-67 was 56.0%. 84.8% of patients showed Ki-67 ≥ 14%. Mean scores of Ki-67 were correlated with grade (p = 0.006), PR (p = 0.026), histological type, ER, combined ER/RP, and molecular subtype (p < 0.001). Ki-67 was independent of HER2 (p = 0.402) and menopausal status (p = 0.471). The frequency of Ki-67 according to St Gallen 2011 was associated with histological type (p = 0.005), grade (p = 0.005), ER (p < 0.001), combined ER/PR (p = 0.004), and molecular subtype (p = 0.004). There was no significant relationship between the distribution of Ki-67 and the age of the patients (p = 0.859), menopausal status (p = 0.979), PR (p = 0.149), and HER2 (p = 0.597). CONCLUSION: Ki-67 is useful for treatment decisions in primary breast cancer patients. The high value of Ki-67 was associated with adverse clinicopathologic factors. The increased Ki-67 value should be carefully investigated in triple negative patients.
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spelling pubmed-64855842019-05-13 Immunohistochemical Evaluation of Ki-67 and Comparison with Clinicopathologic Factors in Breast Carcinomas Aman, Nguiessan Alphonse Doukoure, Brahima Koffi, Kouadio Donatien Koui, Baumaney Sylvanus Traore, Zie Cheick Kouyate, Mohamed Toure, Ibrahiman Effi, Ahoua Benjamin Asian Pac J Cancer Prev Research Article BACKGROUND: Patients primarily received tamoxifen based on their menopausal status due to the lack of immunohistochemistry. A recent study has shown that hormonal receptors were not correlated with menopausal status, and thus, indicating that they present limited therapeutic and prognostic significance in breast cancer management. This study aimed to evaluate Ki-67 value and analyze its association with clinicopathologic parameters in breast cancer patients. METHODS: The formalin-fixed paraffin-embedded breast tissue blocks of 125 patients with primary breast carcinomas were subjected to immunohistochemical analysis using Ventana Benchmark(®) GX automated immunostainer. Analysis of variance and Chi-2 test were used to examine the relationship between Ki-67 and clinicopathologic variables. RESULTS: The mean age of 125 patients included in the study was 47.7 years. The average score of Ki-67 was 56.0%. 84.8% of patients showed Ki-67 ≥ 14%. Mean scores of Ki-67 were correlated with grade (p = 0.006), PR (p = 0.026), histological type, ER, combined ER/RP, and molecular subtype (p < 0.001). Ki-67 was independent of HER2 (p = 0.402) and menopausal status (p = 0.471). The frequency of Ki-67 according to St Gallen 2011 was associated with histological type (p = 0.005), grade (p = 0.005), ER (p < 0.001), combined ER/PR (p = 0.004), and molecular subtype (p = 0.004). There was no significant relationship between the distribution of Ki-67 and the age of the patients (p = 0.859), menopausal status (p = 0.979), PR (p = 0.149), and HER2 (p = 0.597). CONCLUSION: Ki-67 is useful for treatment decisions in primary breast cancer patients. The high value of Ki-67 was associated with adverse clinicopathologic factors. The increased Ki-67 value should be carefully investigated in triple negative patients. West Asia Organization for Cancer Prevention 2019 /pmc/articles/PMC6485584/ /pubmed/30678383 http://dx.doi.org/10.31557/APJCP.2019.20.1.73 Text en Copyright: © Asian Pacific Journal of Cancer Prevention http://creativecommons.org/licenses/BY-SA/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
spellingShingle Research Article
Aman, Nguiessan Alphonse
Doukoure, Brahima
Koffi, Kouadio Donatien
Koui, Baumaney Sylvanus
Traore, Zie Cheick
Kouyate, Mohamed
Toure, Ibrahiman
Effi, Ahoua Benjamin
Immunohistochemical Evaluation of Ki-67 and Comparison with Clinicopathologic Factors in Breast Carcinomas
title Immunohistochemical Evaluation of Ki-67 and Comparison with Clinicopathologic Factors in Breast Carcinomas
title_full Immunohistochemical Evaluation of Ki-67 and Comparison with Clinicopathologic Factors in Breast Carcinomas
title_fullStr Immunohistochemical Evaluation of Ki-67 and Comparison with Clinicopathologic Factors in Breast Carcinomas
title_full_unstemmed Immunohistochemical Evaluation of Ki-67 and Comparison with Clinicopathologic Factors in Breast Carcinomas
title_short Immunohistochemical Evaluation of Ki-67 and Comparison with Clinicopathologic Factors in Breast Carcinomas
title_sort immunohistochemical evaluation of ki-67 and comparison with clinicopathologic factors in breast carcinomas
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485584/
https://www.ncbi.nlm.nih.gov/pubmed/30678383
http://dx.doi.org/10.31557/APJCP.2019.20.1.73
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