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Single Nucleotide Polymorphism in Adiponectin Gene and Risk of Pancreatic Adenocarcinoma
INTRODUCTION: Adiponectin is anti-inflammatory and anti-tumor cytokine secreted exclusively from adipocytes. There is a growing evidence of association between adiponectin gene polymorphism and development of pancreatic cancer. The current study aimed at evaluation of the possible association betwee...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
West Asia Organization for Cancer Prevention
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485589/ https://www.ncbi.nlm.nih.gov/pubmed/30678425 http://dx.doi.org/10.31557/APJCP.2019.20.1.139 |
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author | Mohamed, Amal Ahmed Omar, Heba Ghaffar, Mohamed F Abdel Marie, Mohamad Saeed Ramadan, Mohamed Ezz El Arab Talima, Soha M Daly, Mostufa EL Mahmoud, Seham |
author_facet | Mohamed, Amal Ahmed Omar, Heba Ghaffar, Mohamed F Abdel Marie, Mohamad Saeed Ramadan, Mohamed Ezz El Arab Talima, Soha M Daly, Mostufa EL Mahmoud, Seham |
author_sort | Mohamed, Amal Ahmed |
collection | PubMed |
description | INTRODUCTION: Adiponectin is anti-inflammatory and anti-tumor cytokine secreted exclusively from adipocytes. There is a growing evidence of association between adiponectin gene polymorphism and development of pancreatic cancer. The current study aimed at evaluation of the possible association between selected adiponectin gene polymorphism and the risk of pancreatic cancer. METHODS: Prospective case-control study included 77 patients (29 women and 48 men) with biopsy-proven pancreatic adenocarcinoma and 97 healthy control. Blood samples from all included participants were genotyped for 3 single nucleotide polymorphism (SNPs) of adiponectin genes (rs1501299C>A, rs266729C>G and rs2241766G>T) by PCR. Clinical, biochemical, and radiological data analyzed. RESULTS: We demonstrated a significant association between the three studied SNPs (rs1501299, rs266729, and rs2241766) and increased risk of pancreatic adenocarcinoma (p<0.001). Furthermore, in clinical correlation analysis, Patients with rs2241766 polymorphism have a lower frequency of lymph node involvement (p 0.05). Smoking and older age were independent predictors of pancreatic adenocarcinoma. CONCLUSION: We provided evidence that variants in adiponectin gene might influence the development and progression of pancreatic cancer. |
format | Online Article Text |
id | pubmed-6485589 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | West Asia Organization for Cancer Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-64855892019-05-13 Single Nucleotide Polymorphism in Adiponectin Gene and Risk of Pancreatic Adenocarcinoma Mohamed, Amal Ahmed Omar, Heba Ghaffar, Mohamed F Abdel Marie, Mohamad Saeed Ramadan, Mohamed Ezz El Arab Talima, Soha M Daly, Mostufa EL Mahmoud, Seham Asian Pac J Cancer Prev Research Article INTRODUCTION: Adiponectin is anti-inflammatory and anti-tumor cytokine secreted exclusively from adipocytes. There is a growing evidence of association between adiponectin gene polymorphism and development of pancreatic cancer. The current study aimed at evaluation of the possible association between selected adiponectin gene polymorphism and the risk of pancreatic cancer. METHODS: Prospective case-control study included 77 patients (29 women and 48 men) with biopsy-proven pancreatic adenocarcinoma and 97 healthy control. Blood samples from all included participants were genotyped for 3 single nucleotide polymorphism (SNPs) of adiponectin genes (rs1501299C>A, rs266729C>G and rs2241766G>T) by PCR. Clinical, biochemical, and radiological data analyzed. RESULTS: We demonstrated a significant association between the three studied SNPs (rs1501299, rs266729, and rs2241766) and increased risk of pancreatic adenocarcinoma (p<0.001). Furthermore, in clinical correlation analysis, Patients with rs2241766 polymorphism have a lower frequency of lymph node involvement (p 0.05). Smoking and older age were independent predictors of pancreatic adenocarcinoma. CONCLUSION: We provided evidence that variants in adiponectin gene might influence the development and progression of pancreatic cancer. West Asia Organization for Cancer Prevention 2019 /pmc/articles/PMC6485589/ /pubmed/30678425 http://dx.doi.org/10.31557/APJCP.2019.20.1.139 Text en Copyright: © Asian Pacific Journal of Cancer Prevention http://creativecommons.org/licenses/BY-SA/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License |
spellingShingle | Research Article Mohamed, Amal Ahmed Omar, Heba Ghaffar, Mohamed F Abdel Marie, Mohamad Saeed Ramadan, Mohamed Ezz El Arab Talima, Soha M Daly, Mostufa EL Mahmoud, Seham Single Nucleotide Polymorphism in Adiponectin Gene and Risk of Pancreatic Adenocarcinoma |
title | Single Nucleotide Polymorphism in Adiponectin Gene and Risk of Pancreatic Adenocarcinoma |
title_full | Single Nucleotide Polymorphism in Adiponectin Gene and Risk of Pancreatic Adenocarcinoma |
title_fullStr | Single Nucleotide Polymorphism in Adiponectin Gene and Risk of Pancreatic Adenocarcinoma |
title_full_unstemmed | Single Nucleotide Polymorphism in Adiponectin Gene and Risk of Pancreatic Adenocarcinoma |
title_short | Single Nucleotide Polymorphism in Adiponectin Gene and Risk of Pancreatic Adenocarcinoma |
title_sort | single nucleotide polymorphism in adiponectin gene and risk of pancreatic adenocarcinoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485589/ https://www.ncbi.nlm.nih.gov/pubmed/30678425 http://dx.doi.org/10.31557/APJCP.2019.20.1.139 |
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