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Single Nucleotide Polymorphism in Adiponectin Gene and Risk of Pancreatic Adenocarcinoma

INTRODUCTION: Adiponectin is anti-inflammatory and anti-tumor cytokine secreted exclusively from adipocytes. There is a growing evidence of association between adiponectin gene polymorphism and development of pancreatic cancer. The current study aimed at evaluation of the possible association betwee...

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Autores principales: Mohamed, Amal Ahmed, Omar, Heba, Ghaffar, Mohamed F Abdel, Marie, Mohamad Saeed, Ramadan, Mohamed Ezz El Arab, Talima, Soha M, Daly, Mostufa EL, Mahmoud, Seham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485589/
https://www.ncbi.nlm.nih.gov/pubmed/30678425
http://dx.doi.org/10.31557/APJCP.2019.20.1.139
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author Mohamed, Amal Ahmed
Omar, Heba
Ghaffar, Mohamed F Abdel
Marie, Mohamad Saeed
Ramadan, Mohamed Ezz El Arab
Talima, Soha M
Daly, Mostufa EL
Mahmoud, Seham
author_facet Mohamed, Amal Ahmed
Omar, Heba
Ghaffar, Mohamed F Abdel
Marie, Mohamad Saeed
Ramadan, Mohamed Ezz El Arab
Talima, Soha M
Daly, Mostufa EL
Mahmoud, Seham
author_sort Mohamed, Amal Ahmed
collection PubMed
description INTRODUCTION: Adiponectin is anti-inflammatory and anti-tumor cytokine secreted exclusively from adipocytes. There is a growing evidence of association between adiponectin gene polymorphism and development of pancreatic cancer. The current study aimed at evaluation of the possible association between selected adiponectin gene polymorphism and the risk of pancreatic cancer. METHODS: Prospective case-control study included 77 patients (29 women and 48 men) with biopsy-proven pancreatic adenocarcinoma and 97 healthy control. Blood samples from all included participants were genotyped for 3 single nucleotide polymorphism (SNPs) of adiponectin genes (rs1501299C>A, rs266729C>G and rs2241766G>T) by PCR. Clinical, biochemical, and radiological data analyzed. RESULTS: We demonstrated a significant association between the three studied SNPs (rs1501299, rs266729, and rs2241766) and increased risk of pancreatic adenocarcinoma (p<0.001). Furthermore, in clinical correlation analysis, Patients with rs2241766 polymorphism have a lower frequency of lymph node involvement (p 0.05). Smoking and older age were independent predictors of pancreatic adenocarcinoma. CONCLUSION: We provided evidence that variants in adiponectin gene might influence the development and progression of pancreatic cancer.
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spelling pubmed-64855892019-05-13 Single Nucleotide Polymorphism in Adiponectin Gene and Risk of Pancreatic Adenocarcinoma Mohamed, Amal Ahmed Omar, Heba Ghaffar, Mohamed F Abdel Marie, Mohamad Saeed Ramadan, Mohamed Ezz El Arab Talima, Soha M Daly, Mostufa EL Mahmoud, Seham Asian Pac J Cancer Prev Research Article INTRODUCTION: Adiponectin is anti-inflammatory and anti-tumor cytokine secreted exclusively from adipocytes. There is a growing evidence of association between adiponectin gene polymorphism and development of pancreatic cancer. The current study aimed at evaluation of the possible association between selected adiponectin gene polymorphism and the risk of pancreatic cancer. METHODS: Prospective case-control study included 77 patients (29 women and 48 men) with biopsy-proven pancreatic adenocarcinoma and 97 healthy control. Blood samples from all included participants were genotyped for 3 single nucleotide polymorphism (SNPs) of adiponectin genes (rs1501299C>A, rs266729C>G and rs2241766G>T) by PCR. Clinical, biochemical, and radiological data analyzed. RESULTS: We demonstrated a significant association between the three studied SNPs (rs1501299, rs266729, and rs2241766) and increased risk of pancreatic adenocarcinoma (p<0.001). Furthermore, in clinical correlation analysis, Patients with rs2241766 polymorphism have a lower frequency of lymph node involvement (p 0.05). Smoking and older age were independent predictors of pancreatic adenocarcinoma. CONCLUSION: We provided evidence that variants in adiponectin gene might influence the development and progression of pancreatic cancer. West Asia Organization for Cancer Prevention 2019 /pmc/articles/PMC6485589/ /pubmed/30678425 http://dx.doi.org/10.31557/APJCP.2019.20.1.139 Text en Copyright: © Asian Pacific Journal of Cancer Prevention http://creativecommons.org/licenses/BY-SA/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
spellingShingle Research Article
Mohamed, Amal Ahmed
Omar, Heba
Ghaffar, Mohamed F Abdel
Marie, Mohamad Saeed
Ramadan, Mohamed Ezz El Arab
Talima, Soha M
Daly, Mostufa EL
Mahmoud, Seham
Single Nucleotide Polymorphism in Adiponectin Gene and Risk of Pancreatic Adenocarcinoma
title Single Nucleotide Polymorphism in Adiponectin Gene and Risk of Pancreatic Adenocarcinoma
title_full Single Nucleotide Polymorphism in Adiponectin Gene and Risk of Pancreatic Adenocarcinoma
title_fullStr Single Nucleotide Polymorphism in Adiponectin Gene and Risk of Pancreatic Adenocarcinoma
title_full_unstemmed Single Nucleotide Polymorphism in Adiponectin Gene and Risk of Pancreatic Adenocarcinoma
title_short Single Nucleotide Polymorphism in Adiponectin Gene and Risk of Pancreatic Adenocarcinoma
title_sort single nucleotide polymorphism in adiponectin gene and risk of pancreatic adenocarcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485589/
https://www.ncbi.nlm.nih.gov/pubmed/30678425
http://dx.doi.org/10.31557/APJCP.2019.20.1.139
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