Lkb1 deletion in periosteal mesenchymal progenitors induces osteogenic tumors through mTORC1 activation

Bone osteogenic sarcoma has a poor prognosis, as the exact cell of origin and the signaling pathways underlying tumor formation remain undefined. Here, we report an osteogenic tumor mouse model based on the conditional knockout of liver kinase b1 (Lkb1, also known as Stk11) in Cathepsin K–Cre–expres...

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Detalles Bibliográficos
Autores principales: Han, Yujiao, Feng, Heng, Sun, Jun, Liang, Xiaoting, Wang, Zhuo, Xing, Wenhui, Dai, Qinggang, Yang, Yang, Han, Anjia, Wei, Zhanying, Bi, Qing, Ji, Hongbin, Kang, Tiebang, Zou, Weiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486357/
https://www.ncbi.nlm.nih.gov/pubmed/30830877
http://dx.doi.org/10.1172/JCI124590

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