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Developing OECD test guidelines for regulatory testing of nanomaterials to ensure mutual acceptance of test data

The OECD Working Party on Manufactured Nanomaterials (WPMN) provides a global forum for discussion of nano-safety issues. Together with the OECD Test Guidelines Programme (TGP) the WPMN has explored the need for adaptation of some of the existing OECD Test Guidelines (TGs) and Guidance Documents (GD...

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Autores principales: Rasmussen, Kirsten, Rauscher, Hubert, Kearns, Peter, González, Mar, Riego Sintes, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486396/
https://www.ncbi.nlm.nih.gov/pubmed/30831158
http://dx.doi.org/10.1016/j.yrtph.2019.02.008
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author Rasmussen, Kirsten
Rauscher, Hubert
Kearns, Peter
González, Mar
Riego Sintes, Juan
author_facet Rasmussen, Kirsten
Rauscher, Hubert
Kearns, Peter
González, Mar
Riego Sintes, Juan
author_sort Rasmussen, Kirsten
collection PubMed
description The OECD Working Party on Manufactured Nanomaterials (WPMN) provides a global forum for discussion of nano-safety issues. Together with the OECD Test Guidelines Programme (TGP) the WPMN has explored the need for adaptation of some of the existing OECD Test Guidelines (TGs) and Guidance Documents (GDs) as well as developing new TGs and GDs to specifically address NM issues. An overview is provided of progress in the TGP and WPMN, and information on supporting initiatives, regarding the development of TGs for nanomaterials addressing Physical Chemical Properties, Effects on Biotic Systems, Environmental Fate and Behaviour, and Health Effects. Three TGs specifically addressing manufactured nanomaterials have been adopted: a new TG318 ″Dispersion Stability of Nanomaterials in Simulated Environmental Media”, and adaptation of TG412 and TG413 on Subacute Inhalation Toxicity: 28-Day Study/90-day Study. The associated GD39 on Inhalation Toxicity Testing has also been revised. The TGP current develops four new TGs and four GDs. One new TG and six GDs are developed in the WPMN. Six new proposals were submitted to the TGP in 2018. Furthermore, as TGs are accompanied by OECD harmonised templates (OHTs) for data collection, an outline of recently developed OHTs particularly relevant for NMs is also included.
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spelling pubmed-64863962019-06-01 Developing OECD test guidelines for regulatory testing of nanomaterials to ensure mutual acceptance of test data Rasmussen, Kirsten Rauscher, Hubert Kearns, Peter González, Mar Riego Sintes, Juan Regul Toxicol Pharmacol Article The OECD Working Party on Manufactured Nanomaterials (WPMN) provides a global forum for discussion of nano-safety issues. Together with the OECD Test Guidelines Programme (TGP) the WPMN has explored the need for adaptation of some of the existing OECD Test Guidelines (TGs) and Guidance Documents (GDs) as well as developing new TGs and GDs to specifically address NM issues. An overview is provided of progress in the TGP and WPMN, and information on supporting initiatives, regarding the development of TGs for nanomaterials addressing Physical Chemical Properties, Effects on Biotic Systems, Environmental Fate and Behaviour, and Health Effects. Three TGs specifically addressing manufactured nanomaterials have been adopted: a new TG318 ″Dispersion Stability of Nanomaterials in Simulated Environmental Media”, and adaptation of TG412 and TG413 on Subacute Inhalation Toxicity: 28-Day Study/90-day Study. The associated GD39 on Inhalation Toxicity Testing has also been revised. The TGP current develops four new TGs and four GDs. One new TG and six GDs are developed in the WPMN. Six new proposals were submitted to the TGP in 2018. Furthermore, as TGs are accompanied by OECD harmonised templates (OHTs) for data collection, an outline of recently developed OHTs particularly relevant for NMs is also included. Elsevier 2019-06 /pmc/articles/PMC6486396/ /pubmed/30831158 http://dx.doi.org/10.1016/j.yrtph.2019.02.008 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Rasmussen, Kirsten
Rauscher, Hubert
Kearns, Peter
González, Mar
Riego Sintes, Juan
Developing OECD test guidelines for regulatory testing of nanomaterials to ensure mutual acceptance of test data
title Developing OECD test guidelines for regulatory testing of nanomaterials to ensure mutual acceptance of test data
title_full Developing OECD test guidelines for regulatory testing of nanomaterials to ensure mutual acceptance of test data
title_fullStr Developing OECD test guidelines for regulatory testing of nanomaterials to ensure mutual acceptance of test data
title_full_unstemmed Developing OECD test guidelines for regulatory testing of nanomaterials to ensure mutual acceptance of test data
title_short Developing OECD test guidelines for regulatory testing of nanomaterials to ensure mutual acceptance of test data
title_sort developing oecd test guidelines for regulatory testing of nanomaterials to ensure mutual acceptance of test data
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486396/
https://www.ncbi.nlm.nih.gov/pubmed/30831158
http://dx.doi.org/10.1016/j.yrtph.2019.02.008
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