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Developing OECD test guidelines for regulatory testing of nanomaterials to ensure mutual acceptance of test data
The OECD Working Party on Manufactured Nanomaterials (WPMN) provides a global forum for discussion of nano-safety issues. Together with the OECD Test Guidelines Programme (TGP) the WPMN has explored the need for adaptation of some of the existing OECD Test Guidelines (TGs) and Guidance Documents (GD...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486396/ https://www.ncbi.nlm.nih.gov/pubmed/30831158 http://dx.doi.org/10.1016/j.yrtph.2019.02.008 |
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author | Rasmussen, Kirsten Rauscher, Hubert Kearns, Peter González, Mar Riego Sintes, Juan |
author_facet | Rasmussen, Kirsten Rauscher, Hubert Kearns, Peter González, Mar Riego Sintes, Juan |
author_sort | Rasmussen, Kirsten |
collection | PubMed |
description | The OECD Working Party on Manufactured Nanomaterials (WPMN) provides a global forum for discussion of nano-safety issues. Together with the OECD Test Guidelines Programme (TGP) the WPMN has explored the need for adaptation of some of the existing OECD Test Guidelines (TGs) and Guidance Documents (GDs) as well as developing new TGs and GDs to specifically address NM issues. An overview is provided of progress in the TGP and WPMN, and information on supporting initiatives, regarding the development of TGs for nanomaterials addressing Physical Chemical Properties, Effects on Biotic Systems, Environmental Fate and Behaviour, and Health Effects. Three TGs specifically addressing manufactured nanomaterials have been adopted: a new TG318 ″Dispersion Stability of Nanomaterials in Simulated Environmental Media”, and adaptation of TG412 and TG413 on Subacute Inhalation Toxicity: 28-Day Study/90-day Study. The associated GD39 on Inhalation Toxicity Testing has also been revised. The TGP current develops four new TGs and four GDs. One new TG and six GDs are developed in the WPMN. Six new proposals were submitted to the TGP in 2018. Furthermore, as TGs are accompanied by OECD harmonised templates (OHTs) for data collection, an outline of recently developed OHTs particularly relevant for NMs is also included. |
format | Online Article Text |
id | pubmed-6486396 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-64863962019-06-01 Developing OECD test guidelines for regulatory testing of nanomaterials to ensure mutual acceptance of test data Rasmussen, Kirsten Rauscher, Hubert Kearns, Peter González, Mar Riego Sintes, Juan Regul Toxicol Pharmacol Article The OECD Working Party on Manufactured Nanomaterials (WPMN) provides a global forum for discussion of nano-safety issues. Together with the OECD Test Guidelines Programme (TGP) the WPMN has explored the need for adaptation of some of the existing OECD Test Guidelines (TGs) and Guidance Documents (GDs) as well as developing new TGs and GDs to specifically address NM issues. An overview is provided of progress in the TGP and WPMN, and information on supporting initiatives, regarding the development of TGs for nanomaterials addressing Physical Chemical Properties, Effects on Biotic Systems, Environmental Fate and Behaviour, and Health Effects. Three TGs specifically addressing manufactured nanomaterials have been adopted: a new TG318 ″Dispersion Stability of Nanomaterials in Simulated Environmental Media”, and adaptation of TG412 and TG413 on Subacute Inhalation Toxicity: 28-Day Study/90-day Study. The associated GD39 on Inhalation Toxicity Testing has also been revised. The TGP current develops four new TGs and four GDs. One new TG and six GDs are developed in the WPMN. Six new proposals were submitted to the TGP in 2018. Furthermore, as TGs are accompanied by OECD harmonised templates (OHTs) for data collection, an outline of recently developed OHTs particularly relevant for NMs is also included. Elsevier 2019-06 /pmc/articles/PMC6486396/ /pubmed/30831158 http://dx.doi.org/10.1016/j.yrtph.2019.02.008 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Rasmussen, Kirsten Rauscher, Hubert Kearns, Peter González, Mar Riego Sintes, Juan Developing OECD test guidelines for regulatory testing of nanomaterials to ensure mutual acceptance of test data |
title | Developing OECD test guidelines for regulatory testing of nanomaterials to ensure mutual acceptance of test data |
title_full | Developing OECD test guidelines for regulatory testing of nanomaterials to ensure mutual acceptance of test data |
title_fullStr | Developing OECD test guidelines for regulatory testing of nanomaterials to ensure mutual acceptance of test data |
title_full_unstemmed | Developing OECD test guidelines for regulatory testing of nanomaterials to ensure mutual acceptance of test data |
title_short | Developing OECD test guidelines for regulatory testing of nanomaterials to ensure mutual acceptance of test data |
title_sort | developing oecd test guidelines for regulatory testing of nanomaterials to ensure mutual acceptance of test data |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486396/ https://www.ncbi.nlm.nih.gov/pubmed/30831158 http://dx.doi.org/10.1016/j.yrtph.2019.02.008 |
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