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PrimPol is required for the maintenance of efficient nuclear and mitochondrial DNA replication in human cells

Eukaryotic Primase-Polymerase (PrimPol) is an enzyme that maintains efficient DNA duplication by repriming replication restart downstream of replicase stalling lesions and structures. To elucidate the cellular requirements for PrimPol in human cells, we generated PrimPol-deleted cell lines and show...

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Detalles Bibliográficos
Autores principales:	Bailey, Laura J, Bianchi, Julie, Doherty, Aidan J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486543/ https://www.ncbi.nlm.nih.gov/pubmed/30715459 http://dx.doi.org/10.1093/nar/gkz056

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