Depletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation

DNA double strand break (DSB) repair through homologous recombination (HR) is crucial to maintain genome stability. DSB resection generates a single strand DNA intermediate, which is crucial for the HR process. We used a synthetic DNA structure, mimicking a resection intermediate, as a bait to ident...

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Detalles Bibliográficos
Autores principales: Alfano, Luigi, Caporaso, Antonella, Altieri, Angela, Dell’Aquila, Milena, Landi, Claudia, Bini, Luca, Pentimalli, Francesca, Giordano, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486545/
https://www.ncbi.nlm.nih.gov/pubmed/30799487
http://dx.doi.org/10.1093/nar/gkz076

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