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Depletion of S-adenosylmethionine impacts on ribosome biogenesis through hypomodification of a single rRNA methylation

S-adenosylmethionine (SAM) is an essential metabolite and a methyl group donor in all living organisms. The intracellular SAM concentration is tightly regulated, and depletion causes hypomethylation of substrates, growth defects and pathological consequences. In the emerging field of epitranscriptom...

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Detalles Bibliográficos
Autores principales:	Ishiguro, Kensuke, Arai, Taiga, Suzuki, Tsutomu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486555/ https://www.ncbi.nlm.nih.gov/pubmed/30799486 http://dx.doi.org/10.1093/nar/gkz111

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