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Human-sized magnetic particle imaging for brain applications

Determining the brain perfusion is an important task for diagnosis of vascular diseases such as occlusions and intracerebral haemorrhage. Even after successful diagnosis, there is a high risk of restenosis or rebleeding such that patients need intense attention in the days after treatment. Within th...

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Autores principales: Graeser, M., Thieben, F., Szwargulski, P., Werner, F., Gdaniec, N., Boberg, M., Griese, F., Möddel, M., Ludewig, P., van de Ven, D., Weber, O. M., Woywode, O., Gleich, B., Knopp, T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486595/
https://www.ncbi.nlm.nih.gov/pubmed/31028253
http://dx.doi.org/10.1038/s41467-019-09704-x
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author Graeser, M.
Thieben, F.
Szwargulski, P.
Werner, F.
Gdaniec, N.
Boberg, M.
Griese, F.
Möddel, M.
Ludewig, P.
van de Ven, D.
Weber, O. M.
Woywode, O.
Gleich, B.
Knopp, T.
author_facet Graeser, M.
Thieben, F.
Szwargulski, P.
Werner, F.
Gdaniec, N.
Boberg, M.
Griese, F.
Möddel, M.
Ludewig, P.
van de Ven, D.
Weber, O. M.
Woywode, O.
Gleich, B.
Knopp, T.
author_sort Graeser, M.
collection PubMed
description Determining the brain perfusion is an important task for diagnosis of vascular diseases such as occlusions and intracerebral haemorrhage. Even after successful diagnosis, there is a high risk of restenosis or rebleeding such that patients need intense attention in the days after treatment. Within this work, we present a diagnostic tomographic imager that allows access to brain perfusion quantitatively in short intervals. The device is based on the magnetic particle imaging technology and is designed for human scale. It is highly sensitive and allows the detection of an iron concentration of 263 pmol(Fe) ml(−1), which is one of the lowest iron concentrations imaged by MPI so far. The imager is self-shielded and can be used in unshielded environments such as intensive care units. In combination with the low technical requirements this opens up a variety of medical applications and would allow monitoring of stroke on intensive care units.
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spelling pubmed-64865952019-04-29 Human-sized magnetic particle imaging for brain applications Graeser, M. Thieben, F. Szwargulski, P. Werner, F. Gdaniec, N. Boberg, M. Griese, F. Möddel, M. Ludewig, P. van de Ven, D. Weber, O. M. Woywode, O. Gleich, B. Knopp, T. Nat Commun Article Determining the brain perfusion is an important task for diagnosis of vascular diseases such as occlusions and intracerebral haemorrhage. Even after successful diagnosis, there is a high risk of restenosis or rebleeding such that patients need intense attention in the days after treatment. Within this work, we present a diagnostic tomographic imager that allows access to brain perfusion quantitatively in short intervals. The device is based on the magnetic particle imaging technology and is designed for human scale. It is highly sensitive and allows the detection of an iron concentration of 263 pmol(Fe) ml(−1), which is one of the lowest iron concentrations imaged by MPI so far. The imager is self-shielded and can be used in unshielded environments such as intensive care units. In combination with the low technical requirements this opens up a variety of medical applications and would allow monitoring of stroke on intensive care units. Nature Publishing Group UK 2019-04-26 /pmc/articles/PMC6486595/ /pubmed/31028253 http://dx.doi.org/10.1038/s41467-019-09704-x Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Graeser, M.
Thieben, F.
Szwargulski, P.
Werner, F.
Gdaniec, N.
Boberg, M.
Griese, F.
Möddel, M.
Ludewig, P.
van de Ven, D.
Weber, O. M.
Woywode, O.
Gleich, B.
Knopp, T.
Human-sized magnetic particle imaging for brain applications
title Human-sized magnetic particle imaging for brain applications
title_full Human-sized magnetic particle imaging for brain applications
title_fullStr Human-sized magnetic particle imaging for brain applications
title_full_unstemmed Human-sized magnetic particle imaging for brain applications
title_short Human-sized magnetic particle imaging for brain applications
title_sort human-sized magnetic particle imaging for brain applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486595/
https://www.ncbi.nlm.nih.gov/pubmed/31028253
http://dx.doi.org/10.1038/s41467-019-09704-x
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