Caveolin-1 as a target in prevention and treatment of hypertrophic scarring

Reduced expression of caveolin-1 (Cav-1) is an important pathogenic factor in hypertrophic scarring (HTS). Such a reduction can be found in connection with the main known risk factors for HTS, including dark skin, female gender, young age, burn site and severity of the injury. The degree of overexpr...

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Autores principales: Kruglikov, Ilja L., Scherer, Philipp E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486604/
https://www.ncbi.nlm.nih.gov/pubmed/31044089
http://dx.doi.org/10.1038/s41536-019-0071-x
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author Kruglikov, Ilja L.
Scherer, Philipp E.
author_facet Kruglikov, Ilja L.
Scherer, Philipp E.
author_sort Kruglikov, Ilja L.
collection PubMed
description Reduced expression of caveolin-1 (Cav-1) is an important pathogenic factor in hypertrophic scarring (HTS). Such a reduction can be found in connection with the main known risk factors for HTS, including dark skin, female gender, young age, burn site and severity of the injury. The degree of overexpression of Cav-1 associated with different therapeutic options for HTS correlates with clinical improvements in HTS. This makes endo- or exogenous induction of Cav-1 not only an important therapeutic target for HTS, but also highlights its use as a preventive target to reduce or avoid HTS formation.
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spelling pubmed-64866042019-05-01 Caveolin-1 as a target in prevention and treatment of hypertrophic scarring Kruglikov, Ilja L. Scherer, Philipp E. NPJ Regen Med Perspective Reduced expression of caveolin-1 (Cav-1) is an important pathogenic factor in hypertrophic scarring (HTS). Such a reduction can be found in connection with the main known risk factors for HTS, including dark skin, female gender, young age, burn site and severity of the injury. The degree of overexpression of Cav-1 associated with different therapeutic options for HTS correlates with clinical improvements in HTS. This makes endo- or exogenous induction of Cav-1 not only an important therapeutic target for HTS, but also highlights its use as a preventive target to reduce or avoid HTS formation. Nature Publishing Group UK 2019-04-26 /pmc/articles/PMC6486604/ /pubmed/31044089 http://dx.doi.org/10.1038/s41536-019-0071-x Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Perspective
Kruglikov, Ilja L.
Scherer, Philipp E.
Caveolin-1 as a target in prevention and treatment of hypertrophic scarring
title Caveolin-1 as a target in prevention and treatment of hypertrophic scarring
title_full Caveolin-1 as a target in prevention and treatment of hypertrophic scarring
title_fullStr Caveolin-1 as a target in prevention and treatment of hypertrophic scarring
title_full_unstemmed Caveolin-1 as a target in prevention and treatment of hypertrophic scarring
title_short Caveolin-1 as a target in prevention and treatment of hypertrophic scarring
title_sort caveolin-1 as a target in prevention and treatment of hypertrophic scarring
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486604/
https://www.ncbi.nlm.nih.gov/pubmed/31044089
http://dx.doi.org/10.1038/s41536-019-0071-x
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