Engineering osteoblastic metastases to delineate the adaptive response of androgen-deprived prostate cancer in the bone metastatic microenvironment

While stromal interactions are essential in cancer adaptation to hormonal therapies, the effects of bone stroma and androgen deprivation on cancer progression in bone are poorly understood. Here, we tissue-engineered and validated an in vitro microtissue model of osteoblastic bone metastases, and us...

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Detalles Bibliográficos
Autores principales: Bock, Nathalie, Shokoohmand, Ali, Kryza, Thomas, Röhl, Joan, Meijer, Jonelle, Tran, Phong A., Nelson, Colleen C., Clements, Judith A., Hutmacher, Dietmar W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486620/
https://www.ncbi.nlm.nih.gov/pubmed/31044095
http://dx.doi.org/10.1038/s41413-019-0049-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486620/
https://www.ncbi.nlm.nih.gov/pubmed/31044095
http://dx.doi.org/10.1038/s41413-019-0049-8

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