Cargando…
Environmentally induced nephrotoxicity and histopathological alternations in Wallago attu and Cirrhinus mrigla
Fish kidneys are sensitive to chemical changes in the freshwater ecosystem because they are directly and constantly exposed to chemicals dissolved in the water. This study evaluated nephrotoxicity in Wallago attu and Cirrhinus mrigala harvested from the Chenab River in an area of industrial and sewa...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486624/ https://www.ncbi.nlm.nih.gov/pubmed/31049000 http://dx.doi.org/10.1016/j.sjbs.2019.02.003 |
_version_ | 1783414375502053376 |
---|---|
author | Hussain, Bilal Fatima, Maleeha Al-Ghanim, Khalid Abdullah Mahboob, Shahid |
author_facet | Hussain, Bilal Fatima, Maleeha Al-Ghanim, Khalid Abdullah Mahboob, Shahid |
author_sort | Hussain, Bilal |
collection | PubMed |
description | Fish kidneys are sensitive to chemical changes in the freshwater ecosystem because they are directly and constantly exposed to chemicals dissolved in the water. This study evaluated nephrotoxicity in Wallago attu and Cirrhinus mrigala harvested from the Chenab River in an area of industrial and sewage waste disposal. Induced histological alternation data were correlated to the severity of environmental degradation in order to determine whether this biological system can be used as a tool for environmental monitoring programs. Kidneys from two fish species occupying different niches were collected and stored for 24 h in 10% formalin. Control fish were collected upstream of the polluted river area. Specimens were processed using topical histological methods. The major histological alterations observed in both species were renal tubule myxospora, hyperemia, glomerulonephritis, degeneration of renal tubule cells, dilation of glomerular capillaries, presence of pycnotic nuclei in the hematopoietic tissue, epithelial hypertrophy, vacuolization, reduced lumen of renal tubules, and shrinkage of glomeruli. Renal tubular atrophy, degeneration due to extensive degranulation, necrosis of glomeruli, glomerular expansion, absence of Bowman’s space, hypertrophied nucleus, necrosis and hyalinization of the interstitium, clogging of tubules, and regeneration of tubules was also observed. Wallago attu exhibited the maximum incidence of moderate to severe changes and was defined as having the highest “histopathologic alteration index”. These severe alterations were found to be related to environmental degradation, indicating the presence of stressors in freshwater. Control groups showed normal tissue morphology in the kidneys. |
format | Online Article Text |
id | pubmed-6486624 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-64866242019-05-02 Environmentally induced nephrotoxicity and histopathological alternations in Wallago attu and Cirrhinus mrigla Hussain, Bilal Fatima, Maleeha Al-Ghanim, Khalid Abdullah Mahboob, Shahid Saudi J Biol Sci Article Fish kidneys are sensitive to chemical changes in the freshwater ecosystem because they are directly and constantly exposed to chemicals dissolved in the water. This study evaluated nephrotoxicity in Wallago attu and Cirrhinus mrigala harvested from the Chenab River in an area of industrial and sewage waste disposal. Induced histological alternation data were correlated to the severity of environmental degradation in order to determine whether this biological system can be used as a tool for environmental monitoring programs. Kidneys from two fish species occupying different niches were collected and stored for 24 h in 10% formalin. Control fish were collected upstream of the polluted river area. Specimens were processed using topical histological methods. The major histological alterations observed in both species were renal tubule myxospora, hyperemia, glomerulonephritis, degeneration of renal tubule cells, dilation of glomerular capillaries, presence of pycnotic nuclei in the hematopoietic tissue, epithelial hypertrophy, vacuolization, reduced lumen of renal tubules, and shrinkage of glomeruli. Renal tubular atrophy, degeneration due to extensive degranulation, necrosis of glomeruli, glomerular expansion, absence of Bowman’s space, hypertrophied nucleus, necrosis and hyalinization of the interstitium, clogging of tubules, and regeneration of tubules was also observed. Wallago attu exhibited the maximum incidence of moderate to severe changes and was defined as having the highest “histopathologic alteration index”. These severe alterations were found to be related to environmental degradation, indicating the presence of stressors in freshwater. Control groups showed normal tissue morphology in the kidneys. Elsevier 2019-05 2019-02-05 /pmc/articles/PMC6486624/ /pubmed/31049000 http://dx.doi.org/10.1016/j.sjbs.2019.02.003 Text en © 2019 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Hussain, Bilal Fatima, Maleeha Al-Ghanim, Khalid Abdullah Mahboob, Shahid Environmentally induced nephrotoxicity and histopathological alternations in Wallago attu and Cirrhinus mrigla |
title | Environmentally induced nephrotoxicity and histopathological alternations in Wallago attu and Cirrhinus mrigla |
title_full | Environmentally induced nephrotoxicity and histopathological alternations in Wallago attu and Cirrhinus mrigla |
title_fullStr | Environmentally induced nephrotoxicity and histopathological alternations in Wallago attu and Cirrhinus mrigla |
title_full_unstemmed | Environmentally induced nephrotoxicity and histopathological alternations in Wallago attu and Cirrhinus mrigla |
title_short | Environmentally induced nephrotoxicity and histopathological alternations in Wallago attu and Cirrhinus mrigla |
title_sort | environmentally induced nephrotoxicity and histopathological alternations in wallago attu and cirrhinus mrigla |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486624/ https://www.ncbi.nlm.nih.gov/pubmed/31049000 http://dx.doi.org/10.1016/j.sjbs.2019.02.003 |
work_keys_str_mv | AT hussainbilal environmentallyinducednephrotoxicityandhistopathologicalalternationsinwallagoattuandcirrhinusmrigla AT fatimamaleeha environmentallyinducednephrotoxicityandhistopathologicalalternationsinwallagoattuandcirrhinusmrigla AT alghanimkhalidabdullah environmentallyinducednephrotoxicityandhistopathologicalalternationsinwallagoattuandcirrhinusmrigla AT mahboobshahid environmentallyinducednephrotoxicityandhistopathologicalalternationsinwallagoattuandcirrhinusmrigla |