LARP4A recognizes polyA RNA via a novel binding mechanism mediated by disordered regions and involving the PAM2w motif, revealing interplay between PABP, LARP4A and mRNA

LARP4A belongs to the ancient RNA-binding protein superfamily of La-related proteins (LARPs). In humans, it acts mainly by stabilizing mRNAs, enhancing translation and controlling polyA lengths of heterologous mRNAs. These activities are known to implicate its association with mRNA, protein partners...

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Detalles Bibliográficos
Autores principales: Cruz-Gallardo, Isabel, Martino, Luigi, Kelly, Geoff, Atkinson, R Andrew, Trotta, Roberta, De Tito, Stefano, Coleman, Pierre, Ahdash, Zainab, Gu, Yifei, Bui, Tam T T, Conte, Maria R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486636/
https://www.ncbi.nlm.nih.gov/pubmed/30820564
http://dx.doi.org/10.1093/nar/gkz144

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